3,4,5-三甲氧基苯甲酸合成路线 （共 210 条）
反应条件
2,2'-azo-bisisobutyronitrile; nitric acid in acetonitrile
T=50°C; nitro-Hunsdiecker reaction; 21 h;
参考文献
Das, Jaya Prakash; Sinha, Pradipta; Roy, Sujit
Organic Letters, 2002 , vol. 4, # 18 p. 3055 - 3058
参考文献
Schiffer
Chemische Berichte, 1892 , vol. 25, p. 722
参考文献
Harding
Journal of the Chemical Society, 1911 , vol. 99, p. 1593
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Thoms; Siebeling
Chemische Berichte, 1911 , vol. 44, p. 2116
反应条件
bromine; acetic acid
参考文献
Dallacker,F.
Justus Liebigs Annalen der Chemie, 1963 , vol. 665, p. 78 - 83
参考文献
de Laire; Tiemann
Chemische Berichte, 1893 , vol. 26, p. 2019
反应条件
1: sulfuric acid / 40 - 50 °C
2: pyridine
View Scheme
参考文献
Bogert; Coyne
Journal of the American Chemical Society, 1929 , vol. 51, p. 575
反应条件
1: oxalyl chloride / N,N-dimethylformamide / CH2Cl2
2: 1.83 g / N-ethyl-N,N-diisopropylamine / CH2Cl2
3: 72 percent / hydrazine hydrate / ethanol / 24 h / Heating
View Scheme
参考文献
ALIOS BIOPHARMA, INC.; WANG, Guangyi; BEIGELMAN, Leonid; TRUONG, Anh; NAPOLITANO, Carmela; ANDREOTTI, Daniele; HE, Haiying
Patent: WO2014/31784 A1, 2014 ;
反应条件
1: water containing CHCl3; bromine
2: aqueous NaOH; copper-powder
3: AlBr3; benzene
4: aqueous HCl
View Scheme
参考文献
Mayer; Fikentscher
Chemische Berichte, 1956 , vol. 89, p. 511,517
反应条件
sodium 3,4,5-trimethoxybenzoate
T=190°C;
参考文献
Menon; Venkataraman
Journal of the Chemical Society, 1931 , p. 2591,2596
反应条件
1: sulfuric acid / 40 - 50 °C
2: pyridine
3: benzene; phosphorus pentachloride
View Scheme
参考文献
Bradley; Robinson
Journal of the Chemical Society, 1928 , p. 1551
