6-甲基-N,N-二甲基-2-(4-甲基苯基)-2-羟基咪唑并1,2-alpha吡啶-3-乙酰胺合成路线 （共 7 条）
反应条件
1: With sulfuric acid; sodium bromide in water; acetic acid 2: With hydrogen; 5 Pd-BaSO4 in water; acetic acid P=1551.49 - 2068.65 Torr; 7 h;
参考文献
MALLINCKRODT INC.
Patent: WO2004/58758 A1, 2004 ;
Location in patent: Page 15 ;
反应条件
1: With sulfuric acid; sodium bromide in water; acetic acid 2: With hydrogen; 5 Pd-BaSO4 in water; acetic acid P=1551.49 - 2068.65 Torr; 12.5 h;
参考文献
MALLINCKRODT INC.
Patent: WO2004/58758 A1, 2004 ;
Location in patent: Page 16 ;
参考文献
ScinoPharm Taiwan, Ltd.
Patent: US2004/10146 A1, 2004 ;
Location in patent: Page 2 ;
参考文献
George; Rossey; Depoortere; Mompon; Allen
Farmaco, 1991 , vol. 46, # SUPPL. 1 p. 277 - 288
反应条件
1: With sulfuric acid; hydrogen; acetic anhydride; sodium bromide; palladium on activated charcoal T=80°C; P=2311.54 Torr; 4 h; 2: With ammonium hydroxide in water; isopropyl alcohol T=0 - 40°C; pH=9; Product distribution / selectivity;
参考文献
Jarvi, Esa; Miller, Douglas C.; Moser, Frank W.; Halvachs, Robert E.
Patent: US2007/213537 A1, 2007 ;
Location in patent: Page/Page column 11 ;
反应条件
1: With sulfuric acid; NAF in water 2: With hydrogen; 5 Pd-BaSO4 in water T=70°C; P=1034.32 - 1551.49 Torr; 5 h;
参考文献
MALLINCKRODT INC.
Patent: WO2004/58758 A1, 2004 ;
Location in patent: Page 19 ;
反应条件
sulfuric acid; hydrogen; NAF; acetic acid; 5 Pd-BaSO4 in water T=70°C; P=1034.32 - 1551.49 Torr; 5 h; Product distribution / selectivity;
参考文献
US2007/213537 A1, ;
Page/Page column 10 ;
