N-(2-甲氧基-4-硝基苯基)哌啶合成路线 （共 7 条）
反应条件
1: methanol With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 1 h; 2: 1-(2-fluoro-4-nitrophenyl)piperidine in N,N-dimethyl-formamide T=0°C; 20 h; Heating / reflux;
参考文献
INSTITUTE OF MEDICINAL MOLECULAR DESIGN. INC.
Patent: US2008/227784 A1, 2008 ;
Location in patent: Page/Page column 38 ;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/99771 A2, 2003 ;
Location in patent: Page 71, 95 ;
WO 03/099771 A2
反应条件
water T=20°C; Substitution; 1 h; Irradiation;
参考文献
Mir, Miquel; Marquet, Jordi; Massot, Oriol
Tetrahedron, 1999 , vol. 55, # 43 p. 12603 - 12614
反应条件
in methanol; water 4 h; Ambient temperatureIrradiation;
参考文献
Cantos, Albert; Marquet, Jorge; Moreno-Manas, Marcial; Castello, Assumpta
Tetrahedron, 1988 , vol. 44, # 9 p. 2607 - 2618
参考文献
Lions; Willison
Journal and Proceedings of the Royal Society of New South Wales, 1937 , vol. 71, p. 435,444
参考文献
Lions; Willison
Journal and Proceedings of the Royal Society of New South Wales, 1938 , vol. 71, p. 435,439
反应条件
hydrogen; palladium in ethanol T=20°C; 3 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/99771 A2, 2003 ;
Location in patent: Page 95 ;
WO 03/099771 A2
