N,N-二甲基甲酰胺二乙基缩醛合成路线 （共 152 条）
参考文献
IDENIX PHARMACEUTICALS, INC.; PARSY, Christophe Claude; ALEXANDRE, Francois-Rene; LEROY, Frederic; CONVARD, Thierry; SURLERAUX, Dominique
Patent: WO2011/17389 A1, 2011 ;
Location in patent: Page/Page column 152 ;
WO 2011/017389 A1
反应条件
in N,N-dimethyl-formamide
T=50°C; 1 h;
参考文献
Seela, Frank; Mersmann, Karin; Grasby, Jane A.; Gait, Michael J.
Helvetica Chimica Acta, 1993 , vol. 76, p. 1809 - 1820
反应条件
sodium ethanolate in ethanol
T=20°C; 4.25 h; Reflux;
参考文献
GENENTECH, INC.; ALIAGAS, Ignacio; GRADL, Stefan; GUNZNER, Janet; MATHIEU, Simon; PULK, Rebecca; RUDOLPH, Joachim; WEN, Zhaoyang
Patent: WO2011/25965 A1, 2011 ;
Location in patent: Page/Page column 44 ;
WO 2011/025965 A1
反应条件
in acetonitrile
Ambient temperature;
参考文献
Alves, M. Jose; Carvalho, M. Alice; Proenca, M. Fernanda J.R.P.; Booth, Brian L.; Pritcbard, Robin G.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 3 p. 739 - 743
反应条件
in ethanol
5 h; Heating;
参考文献
Granik, V. G.; Ershov, L. V.; Grizik, S. I.; Chistyakov, V. V.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 9 p. 1026 - 1031
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 9 p. 1252 - 1256
参考文献
Brunner, Henri; Scheck, Thomas
Chemische Berichte, 1992 , vol. 125, # 3 p. 701 - 710
反应条件
in tetrahydrofuran
Reflux;
参考文献
Jones, Raymond C.F.; Iley, James N.; Sanchis-Amat, Maria; Zhang, Xiaohui; Elsegood, Mark R.J.
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3577 - 3579
反应条件
in ethanol
1 h; -40 deg C up to room temperature;
参考文献
Hartke, Klaus; Pfleging, Erwin
Liebigs Annalen der Chemie, 1988 , p. 933 - 942
反应条件
1: β-phenylalanine With potassium bromide; sodium nitrite in sulfuric acid
T=20°C; 1 h;
2: 1,1-diethoxy-N,N-dimethylmethanamine in benzene
0.5 h; Heating;
参考文献
Saniere, Laurent; Schmitt, Martine; Pellegrini, Nadia; Bourguignon, Jean-Jacques
Heterocycles, 2001 , vol. 55, # 4 p. 671 - 688
参考文献
Duguay; Guemas; Meslin; et al.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 4 p. 767 - 770
