3-(4-甲氧基苯氧基)丙醇合成路线 （共 10 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 64 h; Inert atmosphere;
参考文献
Murphy, John A.; Schoenebeck, Franziska; Findlay, Neil J.; Thomson, Douglas W.; Zhou, Sheng-ze; Garnier, Jean
Journal of the American Chemical Society, 2009 , vol. 131, p. 6475 - 6479
反应条件
N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine in N,N-dimethyl-formamide; mineral oil T=20°C; Inert atmosphere;
参考文献
Sword, Ryan; Baldwin, Luke A.; Murphy, John A.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3560 - 3570
反应条件
1: 4-methoxy-phenol With ethanol; sodium T=20°C; 0.5 h; Inert atmosphere; 2: 3-chloropropan-1-ol T=20°C; 9 h; Inert atmosphereReflux;
参考文献
Nawrat, Christopher C.; Moody, Christopher J.
Organic Letters, 2012 , vol. 14, # 6 p. 1484 - 1487
反应条件
1: N-iodo-succinimide 2: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere View Scheme
参考文献
Sword, Ryan; Baldwin, Luke A.; Murphy, John A.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3560 - 3570
反应条件
2: N-iodo-succinimide 3: N,N,N',N'-tetramethyl-7,8-dihydro-6H-dipyrido[1,2-a;2',1'-c][1,4] diazepine-2,12-diamine / N,N-dimethyl-formamide; mineral oil / 20 °C / Inert atmosphere View Scheme
参考文献
Sword, Ryan; Baldwin, Luke A.; Murphy, John A.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3560 - 3570
反应条件
sodium hydroxide; dihydrogen peroxide; diborane 1.) THF, RT, 1 h, 2.) RT, 1 h; Yield given. Multistep reaction;
参考文献
Schvartzapel, Andrea J.; Zhong, Li; Docampo, Roberto; Rodriguez, Juan B.; Gros, Eduardo G.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2314 - 2322
反应条件
1: 1.) KOH / 1.) DMSO, 5 min, 2.) DMSO, RT, 3 h 2: 1.) diborane, 2.) 30percent aq. H2O2, aq. NaOH / 1.) THF, RT, 1 h, 2.) RT, 1 h View Scheme
参考文献
Schvartzapel, Andrea J.; Zhong, Li; Docampo, Roberto; Rodriguez, Juan B.; Gros, Eduardo G.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2314 - 2322
参考文献
Eichinger, Peter C. H.; Bowie, John H.
Organic Mass Spectrometry, 1992 , vol. 27, # 10 p. 995 - 999
参考文献
Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, , vol. 280, p. 39 - 45
反应条件
phosphorus tribromide in diethyl ether
T=-5 - 0°C; Inert atmosphere;
参考文献
Murphy, John A.; Schoenebeck, Franziska; Findlay, Neil J.; Thomson, Douglas W.; Zhou, Sheng-ze; Garnier, Jean
Journal of the American Chemical Society, 2009 , vol. 131, p. 6475 - 6479
