反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.5 h / 160 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C
3.1: tetrahydrofuran; diethyl ether / 0.5 h / 60 °C / |Microwave irradiation
3.2: 0.5 h / 100 °C / |Microwave irradiation
4.1: bromine / dichloromethane / 3 h
View Scheme
参考文献
ZALICUS PHARMACEUTICALS LTD.; PAJOUHESH, Hassan, A.; HOLLAND, Richard; ZHANG, Lingyun; PAJOUHESH, Hossein, O.; LAMONTAGNE, Jason; WHELAN, Brendan; SHORT, Glenn, F., III.; ROMERO, Donna, L.
Patent: WO2013/131018 A1, 2013 ;