3-(3-噻吩基)丙烯酸合成路线 （共 14 条）
反应条件
piperidine in pyridine 1.) 100 deg C, 12 h, 2.) reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 6 p. 1147 - 1156
反应条件
1: With potassium hydroxide in N,N-dimethyl-formamide T=20°C; 4 h; 2: With ammonium chloride in water
参考文献
Synthetic Communications, , vol. 31, # 7 p. 1007 - 1011
反应条件
palladium diacetate; triethylamine; triphenylphosphine in acetonitrile T=120°C; Heck reaction; 20 h;
参考文献
Chemical and pharmaceutical bulletin, , vol. 50, # 5 p. 656 - 660
反应条件
potassium hydroxide 4 h; Heating;
参考文献
Chemistry - A European Journal, , vol. 12, # 10 p. 2739 - 2744
反应条件
1: 91 percent / toluene / 2 h / Heating 2: 90 percent / aq. KOH / 4 h / Heating View Scheme
参考文献
Chemistry - A European Journal, , vol. 12, # 10 p. 2739 - 2744
反应条件
ammonium acetate; ethanol; malonic acid
参考文献
Zhurnal Obshchei Khimii, , vol. 27, p. 464; engl. Ausg. S. 525
反应条件
phenylalanine ammonia-lyase in various solvent(s) T=30°C; pH=8.8; Enzyme kinetics;
参考文献
Chemistry - A European Journal, , vol. 12, # 10 p. 2739 - 2744
反应条件
1: Na/Hg 2: so2cL 3: 5 g / AlCl3 / CS2 / rt, 20 h; reflux, 2h View Scheme
参考文献
Bonini, Bianca Flavia; Capito, Elena; Comes-Franchini, Mauro; Ricci, Alfredo; Bottoni, Andrea; Bernardi, Fernando; Miscione, Gian Pietro; Giordano, Laurent; Cowley, Andrew R.
European Journal of Organic Chemistry, 2004 , # 21 p. 4442 - 4451
反应条件
palladium 10 on activated carbon; hydrogen in methanol; acetic acid T=50°C; 12 h;
参考文献
BioChromix AB; ÅSBERG, Peter; HAMMER, Kristin; OLSSON, Johan; HENRIKSSON, Martin
Patent: WO2013/36196 A1, 2013 ;
Location in patent: Page/Page column 49-50 ;
反应条件
tributyl-amine; triethylamine in diphenylether; water; acetone
参考文献
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Patent: US6034093 A1, 2000 ;
US 6034093 A
