2-甲氧基-4,4,5,5-四甲基-1,3,2-二氧硼戊环合成路线 （共 52 条）
反应条件
1: 4-bromo-1-(1-ethoxyethyl)-1H-pyrazole With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran T=-20 - 20°C; Inert atmosphere; 2: MeOB(pin) in tetrahydrofuran T=-20 - 10°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 11, # 9 p. 1999 - 2002
反应条件
1: 1,4-dibromo-2-fluorobenzene With n-butyllithium in diethyl ether; hexane T=-80°C; 0.5 h; Inert atmosphere; 2: MeOB(pin) in tetrahydrofuran; diethyl ether; hexane T=-70°C; 0.5 h; Inert atmosphere; 3: carbon dioxide Further stages;
参考文献
Kurach, Pawel; Lulinski, Sergiusz; Serwatowski, Janusz
European Journal of Organic Chemistry, 2008 , # 18 p. 3171 - 3178
反应条件
diisobutylaluminum hydride; [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran 3 molpercent Ni-complex, 1.3 equiv of Al-compound, THF, 0-80°C, 24 h;
参考文献
Gao, Fang; Hoveyda, Amir H.
Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 10961 - 10963
反应条件
in tetrahydrofuran; hexane (N2); soln. of PhMe2SiLi in THF added dropwise to stirred soln. of alkoxyborane (2 equiv.) in hexane at 0°C for 30 min; mixt. stirred overnight at room temp.; evapd.; residue was taken up in hexane; filtered under N2; filtrate concd. in vac.; distd. (97-99°C, 0.1 mmHg); elem. anal.;
参考文献
Organometallics, , vol. 19, # 22 p. 4647 - 4649
反应条件
1: 1-ethynyl-3-fluorobenzene With [1,3-bis(diphenylphosphino) propane] dichloronickel(II); diisobutylaluminium hydride in tetrahydrofuran
T=0 - 22°C; Inert atmosphere;
2: MeOB(pin) in tetrahydrofuran
T=0 - 80°C;
3: With water in tetrahydrofuran
T=0 - 22°C;
参考文献
Gao, Fang; Hoveyda, Amir H.
Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 10961 - 10963
反应条件
1: 3,5-diiodopyridine With isopropylmagnesium chloride lithium chloride complex in tetrahydrofuran
T=-78°C; 2 h;
2: MeOB(pin) in tetrahydrofuran
T=-78 - 20°C;
参考文献
Baron, Oliver; Knochel, Paul
Angewandte Chemie - International Edition, 2005 , vol. 44, # 20 p. 3133 - 3135
反应条件
ammonium chloride in tetrahydrofuran
iPrMgCl*LiCl in THF added to soln. at -78°C of C5H3NI2 in THF in dry, argon-flushed Schlenk tube; mixt. stirred for 2 h, until I/Mg exchange; BO2(C(CH3)2)2(OCH3) added; allowed to warm to room. temp., 1 h; quenched with aq. soln. of NH4Cl; extrn. with Et2O; dried over Na2SO4; filtration, soln. evapd. in vac.;
参考文献
Baron, Oliver; Knochel, Paul
Angewandte Chemie - International Edition, 2005 , vol. 44, # 20 p. 3133 - 3135
反应条件
1: 4-methoxy-ortho-bromophenol With n-butyllithium in tetrahydrofuran
T=-78 - 0°C; 1.25 h; Inert atmosphere;
2: MeOB(pin) in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
反应条件
1: 2-bromo-4-methoxy-1-(methoxymethoxy)benzene With n-butyllithium in tetrahydrofuran
T=-78 - 0°C; 1.25 h; Inert atmosphere;
2: MeOB(pin) in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Friedman, Adam A.; Panteleev, Jane; Tsoung, Jennifer; Huynh, Vaizanne; Lautens, Mark
Angewandte Chemie - International Edition, 2013 , vol. 52, # 37 p. 9755 - 9758
反应条件
1: 4-iodo-1-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)-1H-pyrazole With isopropylmagnesium chloride in tetrahydrofuran
T=0°C; 1 h;
2: MeOB(pin) in tetrahydrofuran
T=20°C; 1 h;
3: With water; ammonium chloride in tetrahydrofuran
参考文献
PFIZER INC.
Patent: US2007/265272 A1, 2007 ;
Location in patent: Page/Page column 37; 39 ;
