2-溴-5,5-二甲基-1,3-环己二酮合成路线 （共 36 条）
反应条件
bromine; acetic acid T=20°C; 2 h;
参考文献
UCB PHARMA S.A.
Patent: WO2009/71895 A1, 2009 ;
Location in patent: Page/Page column 95-96 ;
WO 2009/071895 A1
反应条件
1: acetoacetic acid tert-butyl ester With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 1.5 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: cyclohexanone With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 3 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: ethyl acetoacetate With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 1 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: ethyl 3-oxo-3-phenylpropionate With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 3 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: vinyl acetoacetate With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 2 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: acetoacetic acid methyl ester With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 1 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: cyclopentanone With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 3 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: ethyl 2-oxo-cyclohexanecarboxylate With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 1 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
反应条件
1: 2-ethylacetoacetic acid ethyl ester With (DL)-norvaline in dichloromethane 0.0833333 h; 2: 2,2-dibromo-5,5-dimethyl cyclohexane-1,3-dione With dipyridinium dichromate in dichloromethane 2 h; Cooling with ice; optical yield given as percent eeenantioselective reaction;
参考文献
Goswami, Papori; Baruah, Abhilasha; Das, Babulal
Advanced Synthesis and Catalysis, 2009 , vol. 351, # 10 p. 1483 - 1487
