1: N-phenyl-N,N-di(2-hydroxyethyl)amine With triethylamine; acetyl chloride in tetrahydrofuran 2: N,N-dimethyl-formamide With trichlorophosphate T=70°C; Vilsmeyer-Haack formylation; 3: With sodium carbonate in methanol; water T=20°C;
参考文献
Bouder, Thomas Le; Viau, Lydie; Guegan, Jean-Paul; Maury, Olivier; Bozec, Hubert Le
European Journal of Organic Chemistry, 2002 , # 17 p. 3024 - 3033
1.1: trichlorophosphate / 1,2-dichloro-ethane / 0.17 h / 0 °C
1.2: 3 h / Reflux
2.1: potassium permanganate / pyridine; water / 20 h / 20 °C
View Scheme