3,4-二甲氧基苯甲醛合成路线 （共 996 条）
反应条件
in tetrahydrofuran; dimethyl sulfoxide 1.) 0-5 deg C, 15 min., 2.) r.t. 90 min.,;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 3 p. 745 - 750
反应条件
1: 1.) bis(trimethylsilyl)amide / 1.) THF, r.t., 30 min, 2.) THF, r.t., 20 min 2: 96 percent / dimethyldioxirane / acetone / 0.67 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 15 p. 2243 - 2246
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride 1a) 0 deg C, 15 min, 1b) benzene, 18-20 deg C, few minutes, 2) benzene, 50 deg C, 10 h; Yield given. Multistep reaction;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 1018 - 1020
反应条件
1: acetylacetone With diboron trioxide in ethyl acetate T=40°C; Aldol condensation; 0.5 h; 2: 3,4-dimethoxy-benzaldehyde With tributoxyborane in ethyl acetate T=40°C; Aldol condensation; 0.5 h; 3: With N-butylamine in ethyl acetate T=40°C; Aldol condensation; 24.25 h;
参考文献
Amolins, Michael W.; Peterson, Laura B.; Blagg, Brian S.J.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 360 - 367
反应条件
piperidine; boron triethoxide; boron oxide in 1,4-dioxane
参考文献
Konno, Hiroyuki; Endo, Hitoshi; Ise, Satomi; Miyazaki, Keiki; Aoki, Hideo; Sanjoh, Akira; Kobayashi, Kazuya; Hattori, Yasunao; Akaji, Kenichi
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 685 - 690
反应条件
1: 79 percent / NaOH / ethanol / 1) 5 h, reflux, 2) 16 h, 20 deg C 2: 90 percent / H2 / 5percent Pd/C / aq. HCl; methanol / 20 °C 3: 1.32 g / HCl / 1) reflux, 34 h, 2) 4 deg C, 15 h View Scheme
参考文献
Turchin, K. F.; Yanina, A. D.; Filipenko, T. Ya.; Mikhlina, E. E.; Sheinker, Yu. N.; Yakhtonov, L. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1039 - 1048
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1248 - 1256
反应条件
1: 1.) N,N,N'-trimethylethylenediamine, n-BuLi, 2.) hexachloroethane / 1.) THF, from -70 deg C to -30 deg C, 8 h, 2.) THF, RT, 3 h 2: 95 percent / ammonium acetate / acetic acid / 3 h / Heating 3: 80 percent / LiAlH4, AlCl3 / tetrahydrofuran / 16 h / Ambient temperature 4: Me3SiI / CHCl3; tetrahydrothiophene 1,1-dioxide / 72 h / 50 °C View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: With piperidinium acetate in ethanol 0.5 h; 2: With sodium cyanoborohydride in ethanol T=0 - 20°C;
参考文献
Fillion, Eric; Fishlock, Dan; Wilsily, Ashraf; Goll, Julie M.
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1316 - 1327
反应条件
formic acid; triethylamine in methanol; ethanol; chloroform; water
参考文献
BIOGAL GYOGYSZERGYAR
Patent: EP578849 A1, 1994 ;
反应条件
hydrogenchloride; formic acid in N-methyl-acetamide; water
参考文献
BIOGAL GYOGYSZERGYAR
Patent: EP578849 A1, 1994 ;
