3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: Et3N / CH2Cl2 / 1 h / 0 °C 2: 2.1 g / ICl / CH2Cl2 / 20 °C View Scheme
参考文献
Ito, Katsuji; Akashi, Suemi; Saito, Bunnai; Katsuki, Tsutomu
Synlett, 2003 , # 12 p. 1809 - 1812
反应条件
1: 80 percent / 3 h / 170 °C 2: 90 percent / POCl3 / CHCl3 / 3 h / Heating View Scheme
参考文献
Tandon; Barthwal; Bhalla; Bhargava
Arzneimittel-Forschung/Drug Research, 1982 , vol. 32, # 10 p. 1233 - 1235
反应条件
in toluene 72 h; Heating;
参考文献
Feller, Dennis R.; Miller, Duane D.
Patent: US2004/19079 A1, 2004 ;
Location in patent: Page/Page column 17; 29 ;
US 20040019079 A1
反应条件
PPA in dichloromethane T=80°C; 3 h;
参考文献
Tetrahedron, , vol. 52, # 37 p. 12299 - 12308
反应条件
1: 58 percent / toluene / 72 h / Heating 2: POCl3 / acetonitrile / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 19 p. 3701 - 3711
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
chloroformic acid ethyl ester; triethylamine
参考文献
Benovsky, Petr; Stille, John R.
Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8475 - 8478
反应条件
1: 2.) POCl3, P2O5 / 2.) xylene, reflux, 3 h 2: 54 percent / phosphoruspentasulphide / pyridine / 2.5 h / Heating View Scheme
参考文献
Sharma, S. D.; Mehra, Usha; Gupta, P. K.
Tetrahedron, 1980 , vol. 36, p. 3427 - 3430
反应条件
1: POCl3 / toluene / 3.5 h / 20 - 120 °C 2: NaBH4 / methanol / 2.5 h / 20 °C View Scheme
参考文献
Kaur, Jaskiran; Ghosh, Narendra Nath; Talwar, Anita; Chandra, Ramesh
Chemical and pharmaceutical bulletin, 2002 , vol. 50, # 9 p. 1223 - 1228
反应条件
und Erwaermen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Spaeth; Berger
Chemische Berichte, 1930 , vol. 63, p. 2098,2100
