3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
in toluene
18 h; Heating;
参考文献
Hoefgen, Barbara; Decker, Michael; Mohr, Patrick; Schramm, Astrid M.; Rostom, Sherif A. F.; El-Subbagh, Hussein; Schweikert, Peter M.; Rudolf, Dirk R.; Kassack, Matthias U.; Lehmann, Jochen
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 760 - 769
反应条件
1: POCl3
View Scheme
参考文献
Neuvonen, Kari; Fueloep, Ferenc; Neuvonen, Helmi; Koch, Andreas; Kleinpeter, Erich; Pihlaja, Kalevi
Journal of Organic Chemistry, 2005 , vol. 70, # 26 p. 10670 - 10678
反应条件
1: With trichlorophosphate in toluene
T=140°C; Bischler-Napieralski reaction; 0.5 h; Microwave irradiation;
2: With sodium hydroxide in water
pH=8; Cooling;
参考文献
Awuah, Emelia; Capretta, Alfredo
Journal of Organic Chemistry, 2010 , vol. 75, # 16 p. 5627 - 5634
反应条件
1: 20percent aq. sodium hydroxide / diethyl ether / Ambient temperature
2: phosphorus pentoxide, phosphorus oxychloride / xylene / 3 h / Heating
View Scheme
参考文献
Cortes Cortes; Cortes Romero; Gutierrez Ramirez
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 6 p. 1425 - 1427
反应条件
sulfur
T=165 - 175°C;
参考文献
Nakova, E.P.; Tolkachev, O.N.; Evstigneeva, R.P.
Journal of Organic Chemistry USSR (English Translation), 1981 , vol. 17, p. 550 - 555
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 3 p. 637 - 642
反应条件
1: dichloromethane / 18 h / 18 - 20 °C / Inert atmosphere
2: trichlorophosphate / toluene / 2 h / 20 - 111 °C / Inert atmosphere
View Scheme
参考文献
Barker, John M.; Huddleston, Patrick R.; Clephane, Janette; Wood, Michael L.; Holmes, David
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 275 - 282
反应条件
triethylamine in dichloromethane
参考文献
Pitts; Harrison; Moody
Journal of the Chemical Society. Perkin Transactions 1, 2001 , # 9 p. 955 - 977
反应条件
in dichloromethane
T=18 - 20°C; 18 h; Inert atmosphere;
参考文献
Soni, Rina; Cheung, Fung Kei; Clarkson, Guy C.; Martins, Jose E. D.; Graham, Mark A.; Wills, Martin
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 9 p. 3290 - 3294
参考文献
Leseche, Bernard; Gilbert, Jacques; Viel, Claude
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 143 - 153
反应条件
1: 70 percent / Et3N, DMAP / CH2Cl2 / Ambient temperature
2: 60 percent / Et3N, DMAP / CH2Cl2 / Heating
3: 95 percent / n-BuLi / tetrahydrofuran; hexane / a) 0 deg C, 75 min, b) RT, overnight
View Scheme
参考文献
Lete, Esther; Collado, M. Isabel; Sotomayor, Nuria; Vicente, Teresa; Villa, Maria-Jesus
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1751 - 1758
