3,4-二甲氧基苯乙胺合成路线 （共 365 条）
反应条件
1: 2-(3,4-dimethoxyphenyl)-ethylamine; 4-formyl-3,5-dimethoxyphenoxy-Merrifield resin With sodium tris(acetoxy)borohydride in acetic acid; N,N-dimethyl-formamide T=20°C; Solid phase reaction; reductive amination; 69 h; 2: chloroacetic acid With benzotriazol-1-ol; dicyclohexyl-carbodiimide in N,N-dimethyl-formamide T=20°C; Solid phase reaction; acylation; 15 h; 3: With dimethylsulfide; water; trifluoroacetic acid in dichloromethane T=20°C; Solid phase reaction; cleavage of amide; 15 h;
参考文献
Pegurier, C.Ecile; Curtet, Sophie; Nicolas, Jean-Paul; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Langlois, Michel
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 163 - 171
反应条件
potassium hydroxide T=20°C; 3 h;
参考文献
Moehrle; Breves
Pharmazie, 2003 , vol. 58, # 3 p. 181 - 191
反应条件
1: α-phenylbenzeneacetic acid; 4-methyl-benzoic acid With thionyl chloride Combinatorial reaction / High throughput screening (HTS); 2: 2-(4-hydroxyphenyl)ethylamine; 1-adamantaneamine; 2-(4-methylphenyl)-ethylamine; 2-(3,4-dimethoxyphenyl)-ethylamine; phenethylamine; 2-(4-methoxy-phenyl)ethylamine; 3,4,5-trimethoxy-phenylamine; 2-(3-methoxy-phenyl)-ethylamine; 1-amino-2-(2-methoxyphenyl)ethane; (1R*,2S*)-2-methylamino-1-phenyl-1-propanol
参考文献
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
Patent: WO2005/44191 A2, 2005 ;
Location in patent: Figure 12 ;
反应条件
dihydrogen peroxide in ethanol Heating;
参考文献
Viel,C. et al.
Bulletin de la Societe Chimique de France, 1967 , p. 431 - 440
反应条件
triethylamine in tetrahydrofuran 12 h;
参考文献
McKillop, Alexander; Davies, Huw M. L.; Taylor, Edward C.
Synthetic Communications, 1986 , vol. 16, # 3 p. 267 - 282
反应条件
in 3-methyl-1-butanol 12 h; Heating;
参考文献
Corsano; Strappaghetti; Scapicchi
Archiv der Pharmazie, 1992 , vol. 325, # 3 p. 187 - 191
反应条件
triethylamine in dichloromethane
参考文献
SHELL INTERNATIONALE RESEARCH, MAATSCHAPPIJ B.V.
Patent: EP491441 A1, 1992 ;
反应条件
hydrogenchloride in dichloromethane
参考文献
Arndts, Dietrich; Loesel, Walter; Gaida, Wolfram; Klinder, Klaus; Blech, Stefan Matthias; Draheim, Hennig
Patent: US2002/45640 A1, 2002 ;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 7 p. 2585 - 2589
反应条件
in tetrahydrofuran T=20°C; 16 h;
参考文献
Organic Letters, , vol. 12, # 7 p. 1396 - 1399
