5-氨基-1-(2,6-二氯-对三氟甲基苯胺基)-3-腈-4-三氟甲基硫基吡唑合成路线 （共 19 条）
反应条件
in dichloromethane T=18 - 20°C; 12 h; Large scale;
参考文献
WO2013/37291 A1, ;
Page/Page column 16; 17 ;
反应条件
1: 5-amino-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-thiocyanato-1H-pyrazole-3-carbonitrile With sulfur dioxide; sodium formate in DMF (N,N-dimethyl-formamide) T=20°C; 0.0833333 h; 2: monobromotrifluoromethane in DMF (N,N-dimethyl-formamide) T=20 - 45°C; P=8625.86 Torr; 1.5 h; Product distribution / selectivity;
参考文献
WO2005/44806 A1, ;
Page/Page column 7-8; 12 ;
反应条件
1: With dimethylamine p-toluenesulfonate in N,N-dimethyl-formamide; toluene T=20 - 25°C; 0.75 h; 2: With phosphorus trichoride in N,N-dimethyl-formamide; toluene T=0 - 70°C; 8 h; Product distribution / selectivity;
参考文献
WO2009/77853 A1, ;
Page/Page column 28-29 ;
反应条件
sulfur dioxide; sodium formate in N,N-dimethyl-formamide T=60°C; P=9000.7 - 9750.8 Torr; 4 h; other reagent, other perhalogenoalkanes, other disulfide; MechanismProduct distribution;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3371 - 3376
反应条件
lithium chloride in 1-methyl-pyrrolidin-2-one; water
反应条件
trifluoroacetic anhydride; sodium iodide in acetone T=0°C; 10 h;
参考文献
Tetrahedron Letters, , vol. 42, # 32 p. 5371 - 5372
反应条件
sodium formate; sodium hydrogencarbonate in water; N,N-dimethyl-formamide
反应条件
in N-methyl-acetamide; water
参考文献
US2013/30190 A1, ;
Paragraph 0074 ;
反应条件
1.1: dimethylsulfone; potassium fluoride; ammonia / 6 h / 30 - 235 °C / 18751.9 - 19502 Torr / |Autoclave 2.1: sulfuryl dichloride; 1-methyl-pyrrolidin-2-one / 1-methyl-pyrrolidin-2-one; chlorobenzene / 8 h / 55 - 60 °C 3.1: nitrosyl-sulphuric acid; acetic acid / 30 - 55 °C 3.2: 0 - 15 °C 4.1: dichloromethane View Scheme
