5-氨基-3-氰基-1-(2,6-二氯-4-三氟甲基苯基)吡唑合成路线 （共 20 条）
反应条件
ammonia in chlorobenzene; acetonitrile
参考文献
Bayer Cropscience SA
Patent: US6620943 B1, 2003 ;
反应条件
trichlorophosphate; dimethylamine p-toluenesulfonate T=40°C; 14 h; Product distribution / selectivity;
参考文献
VETOQUINOL
Patent: WO2009/77853 A1, 2009 ;
Location in patent: Page/Page column 33-36 ;
反应条件
1: potassium triflinate With thionyl chloride; triethyl amine hydrochloride in toluene T=0 - 5°C; 0.5 - 0.833333 h; 2: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile in toluene T=5 - 35°C; 11.75 h; Product distribution / selectivity;
参考文献
BASF SE
Patent: WO2008/55877 A1, 2008 ;
Location in patent: Page/Page column 23-24; 26-27 ;
参考文献
Rhone-Poulenc Agrochimie
Patent: US5618945 A1, 1997 ;
反应条件
1: trifluoromethanesulphinic acid With thionyl chloride; triethylamine in toluene T=0 - 5°C; 0.5 h; 2: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile With triethyl amine hydrochloride in toluene T=50°C; 6 h; Product distribution / selectivity;
参考文献
BASF SE
Patent: US2011/190510 A1, 2011 ;
Location in patent: Page/Page column 4 ;
反应条件
pyridine hydrochloride in toluene T=0 - 35°C; 11.75 h; Product distribution / selectivity;
参考文献
BASF SE
Patent: WO2008/55877 A1, 2008 ;
Location in patent: Page/Page column 31 ;
反应条件
1: CH2Cl2 / 2 h / Heating 2: KMnO4; MgSO4 / acetone; H2O / 20 °C View Scheme
参考文献
Hainzl, Dominik; Cole, Loretta M.; Casida, John E.
Chemical Research in Toxicology, 1998 , vol. 11, # 12 p. 1529 - 1535
反应条件
in dichloromethane T=18 - 20°C; 12 h; Large scale;
参考文献
WO2013/37291 A1, ;
Page/Page column 16; 17 ;
反应条件
1: With dimethylamine p-toluenesulfonate in N,N-dimethyl-formamide; toluene T=20 - 25°C; 0.75 h; 2: With phosphorus trichoride in N,N-dimethyl-formamide; toluene T=0 - 70°C; 8 h; Product distribution / selectivity;
参考文献
WO2009/77853 A1, ;
Page/Page column 28-29 ;
参考文献
US2013/30190 A1, ;
Paragraph 0074 ;
