(E)-3-[2-(7-氯-2-喹啉基)乙烯基]苯甲醛合成路线 （共 17 条）
反应条件
acetic anhydride in toluene T=100 - 105°C; 12 - 15 h;
参考文献
WO2006/21974 A1, ;
Page/Page column 19-20 ;
反应条件
acetic acid T=100°C; Product distribution / selectivity;
参考文献
US2010/22777 A1, ;
Page/Page column 4-5 ;
反应条件
in benzene-1,3-dicarbaldehyde
参考文献
US5322847 A1, ;
US 5322847 A
反应条件
lithium hydroxide in tetrahydrofuran; methanol T=23°C; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 24 p. 8518 - 8525
反应条件
1: 99 percent / Et3N, 4-DMAP / CH2Cl2 / 0.25 h 2: 69 percent / NBS, (BzO)2 / CCl4 / 3 h / Heating 3: 1 N LiOH / tetrahydrofuran; methanol / 24 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 24 p. 8518 - 8525
反应条件
1: 69 percent / NBS, (BzO)2 / CCl4 / 3 h / Heating 2: 1 N LiOH / tetrahydrofuran; methanol / 24 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 24 p. 8518 - 8525
反应条件
1: 92 percent / toluene; tetrahydrofuran / 1 h / 0 - 5 °C 2: 83 percent / Et3N / Pd(OAc)2 / acetonitrile / 12 h / Heating 3: 87.1 percent / (-)-α-pinene, chloroborane-methyl sulfide, diisopropylethylamine / hexane; tetrahydrofuran / 1) -20 deg C, 3.5 h, 2) to 0 deg C, 1 h View Scheme
参考文献
King; Corley; Anderson; Larsen; Verhoeven; Reider
Journal of Organic Chemistry, 1993 , vol. 58, # 14 p. 3731 - 3735
反应条件
1: in toluene T=-10 - 0°C; 2 h; 2: With water; acetic acid in toluene T=10°C;
参考文献
MOREPEN LABORATORIES LIMITED
Patent: WO2006/21974 A1, 2006 ;
Location in patent: Page/Page column 29-30 ;
反应条件
1: in tetrahydrofuran; toluene T=0 - 10°C; 1.5 h; 2: With ammonium acetate; water in tetrahydrofuran; toluene 1 h;
参考文献
Lonza AG
Patent: EP1988079 A1, 2008 ;
Location in patent: Page/Page column 8-9 ;
反应条件
vinyl-magnesium bromide in tetrahydrofuran T=0 - 5°C; 1 h;
参考文献
King; Corley; Anderson; Larsen; Verhoeven; Reider
Journal of Organic Chemistry, 1993 , vol. 58, # 14 p. 3731 - 3735
