(1R,2R)-(-)-1,2-二环己基-1,2-乙二醇合成路线 （共 11 条）
反应条件
boric acid trimethyl ester; hydrogen; Rhodium trichloride; aluminium in methanol T=55°C; P=4654.46 Torr; 76 h;
参考文献
O'Donnell, Martin J.; Cooper, Jeremy T.; Mader, Mary M.
Journal of the American Chemical Society, 2003 , vol. 125, # 9 p. 2370 - 2371
反应条件
1: With sodium hydroxide; TAPS in diethyl ether; water T=20°C; Hydrolysis; transesterification; 18 h; 2: With hydrogenchloride; water Hydrolysis;
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 6047 - 6051
反应条件
in hexane T=0°C; 36 h;
参考文献
Bahnck, Kevin B.; Rychnovsky, Scott D.
Chemical Communications, 2006 , # 22 p. 2388 - 2390
反应条件
1: With manganese; chloro-trimethyl-silane; (R)-binaphthyl-bis(8-quinolinato); Cr(II) derivative in acetonitrile T=20°C; 2: With sulfuric acid in 1,4-dioxane; ethylene glycol T=90°C; 24 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 126, # 41 p. 13198 - 13199
反应条件
1.1: Mg / tetrahydrofuran / 0 - 20 °C 1.2: 89 percent / tetrahydrofuran / -78 - 20 °C 2.1: 90 percent / aq. NaOH; aq. H2O2 / diethyl ether / 16 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 23 p. 8123 - 8125
反应条件
1: (R,R)-1,2-dicyclohexylethanediol (R)-[1-(benzyloxy)ethyl]boronate With sodium hydroxide; 2,2-bis(hydroxymethyl)-1,3-propanediol; TAPS in diethyl ether; water T=20°C; Hydrolysis; transesterification; 18 h; 2: With hydrogenchloride; water T=0°C; Hydrolysis; pH=3; 3: (S,S)-(-)-1,2-dicyclohexyl-ethane-1,2-diol in hexane Esterification; 18 h;
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 6047 - 6051
反应条件
1.1: Mg / tetrahydrofuran / 0 - 20 °C 1.2: 90 percent / tetrahydrofuran / -78 - 20 °C 2.1: 90 percent / aq. NaOH; aq. H2O2 / diethyl ether / 16 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 23 p. 8123 - 8125
反应条件
1.1: ZnCl2 3.1: 3-{[tris(hydroxymethyl)methyl]amino}propanesulfonic acid; sodium hydroxide / diethyl ether; H2O / 18 h / 20 °C 3.2: 99 percent / hydrochloric acid; water View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 6047 - 6051
反应条件
Multistep reaction.;
参考文献
Bahnck, Kevin B.; Rychnovsky, Scott D.
Chemical Communications, 2006 , # 22 p. 2388 - 2390
反应条件
1: 19 percent / BF3*Et2O / 1,2-dimethoxy-ethane / 72 h / Ambient temperature 2: 141 mg / 3 percent HCl / dioxane; acetonitrile / 1 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 55, # 25 p. 7907 - 7914
