甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
1: 81 percent / KOH / methanol; H2O / 4 h / Heating 2: thionyl chloride / 1 h / Heating 3: 1.) Mg / 1.) THF, 30 min, reflux; 2.) THF, 12 h, room temperature View Scheme
参考文献
Laatsch, Hartmut; Pudleiner, Heinz
Liebigs Annalen der Chemie, 1989 , p. 863 - 882
反应条件
sodium t-butanolate in tetrahydrofuran Rate constant;
参考文献
Stanton, Matthew G.
Journal of the American Chemical Society, 1998 , vol. 120, # 24 p. 5981 - 5989
反应条件
sodium hexamethyldisilazane in tetrahydrofuran T=110°C; 24 h;
参考文献
Synthesis, , # 3 p. 329 - 332
反应条件
ammonia; borophosphoric acid T=380 - 420°C; Yield given;
参考文献
Suvorov, B. V.; Vorob'ev, P. B.; Erzhanov, A. A.; Li, L. V.
J. Appl. Chem. USSR (Engl. Transl.), 1991 , vol. 64, # 12 p. 227 - 229,217 - 219
反应条件
N-methyl-2-(methylamino)ethylamine in toluene 1 h; Heating;
参考文献
Chung, Eun-Ae; Cho, Chang-Woo; Ahn, Kyo Han
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7590 - 7591
反应条件
iodine; magnesium; triethylamine benzene or toluene, Et2O; Yield given. Multistep reaction;
参考文献
Kikkawa, Ikuo; Yorifuji, Tadahiko
Synthesis, 1980 , # 11 p. 877 - 880
反应条件
(i) NaH, THF, (ii) nBuLi, hexane, (iii) /BRN= 2208571/; Multistep reaction;
参考文献
Huckin,S.N.; Weiler,L.
Canadian Journal of Chemistry, 1974 , vol. 52, p. 1343 - 1351
反应条件
tetrahydrofuran; n-butyllithium
参考文献
Beam,C.F. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 1806 - 1810
反应条件
hydroxylamine hydrochloride; potassium hydroxide in methanol
24 h; Reflux;
参考文献
Kreye, Oliver; Wald, Sarah; Meier, Michael A. R.
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 1 p. 81 - 86
反应条件
1: sodium hydride / dimethyl sulfoxide / 8 °C
2: potassium tert-butylate / tetrahydrofuran / Reflux
View Scheme
参考文献
Schaefer, Anja; Wellner, Anja; Gust, Ronald
ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803
