甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
1: hydrazine
2: pyridine / Heating
View Scheme
参考文献
Gierczyk, Blazej; Zalas, MacIej; Kazmierczak, Marcin; Grajewski, Jakub; Pankiewicz, Radoslaw; Wyrzykiewicz, Bozena
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 10 p. 648 - 654
反应条件
1: 94.4 percent / LiAlH4 / diethyl ether / 4 h / Heating
2: 93.8 percent / SOCl2 / diethyl ether / 3 h / 20 °C
3: 4 h / Heating
4: NaOEt / dimethylformamide; ethanol / 3 h / 20 °C
5: BBr3 / CH2Cl2 / -10 - 0 °C
View Scheme
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
反应条件
1: 1-bromo-2,4-dimethoxy-benzene With iodine; magnesium in tetrahydrofuran
0.333333 h;
2: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate in tetrahydrofuran
T=-78°C;
参考文献
Yang, Youjun; Escobedo, Jorge O.; Wong, Alexander; Schowalter, Corin M.; Touchy, Michael C.; Jiao, Lijuan; Crowe, William E.; Fronczek, Frank R.; Strongin, Robert M.
Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6907 - 6912
参考文献
Lund
Journal of the American Chemical Society, 1927 , vol. 49, p. 1348
反应条件
1: NaH / tetrahydrofuran / 48 h / 65 °C
2: hydrazine; HCl / ethanol / 8 h / 80 °C
View Scheme
参考文献
Compton, Dennis R.; Carlson, Kathryn E.; Katzenellenbogen, John A.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5681 - 5684
反应条件
potassium tert-butylate in tetrahydrofuran
Ambient temperature;
参考文献
Stanton, Matthew G.; Gagne, Michel R.
Journal of Organic Chemistry, 1997 , vol. 62, # 23 p. 8240 - 8242
反应条件
sodium t-butanolate in tetrahydrofuran
Rate constant;
参考文献
Stanton, Matthew G.
Journal of the American Chemical Society, 1998 , vol. 120, # 24 p. 5981 - 5989
反应条件
1: hydrazine
2: pyridine / Heating
3: trichlorophosphate / 10 h / Reflux
View Scheme
参考文献
Gierczyk, Blazej; Zalas, MacIej; Kazmierczak, Marcin; Grajewski, Jakub; Pankiewicz, Radoslaw; Wyrzykiewicz, Bozena
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 10 p. 648 - 654
反应条件
1: N2H4*H2O
2: aq. AcOOH
View Scheme
参考文献
Gierczyk, Blazej; Zalas, MacIej; Kazmierczak, Marcin; Grajewski, Jakub; Pankiewicz, Radoslaw; Wyrzykiewicz, Bozena
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 10 p. 648 - 654
反应条件
sec.-butyllithium
Yield given. Multistep reaction;
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
