甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
n-butyllithium
1.) THF, hexane, 35 deg C, 4 h, 2.) THF, hexane, -20 deg C, 3 h; Yield given. Multistep reaction;
参考文献
Houlihan; Gogerty; Parrino; Ryan
Journal of Medicinal Chemistry, 1983 , vol. 26, # 5 p. 765 - 768
反应条件
1: ortho-N-trimethylsilyl-toluidine With n-butyllithium in hexane
Heating;
2: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate in hexane
7 h; Heating; Further stages.;
参考文献
Mahboobi, Siavosh; Eichhorn, Emerich; Winkler, Matthias; Sellmer, Andreas; Moellmann, Ute
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 3 p. 633 - 656
参考文献
Warner-Lambert Company
Patent: US4056619 A1, 1977 ;
反应条件
n-butyllithium in tetrahydrofuran; hexane
1.) -95 deg C, 2 h, 2.) -78 deg C, 30 min;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Degani, Iacopo; Dughera, Stefano; Fochi, Rita
Journal of Organic Chemistry, 1995 , vol. 60, # 19 p. 6017 - 6024
反应条件
lanthanum (III) nitrate * water; [MeP(octyl)3][OCOOCH3] in hexane
10 h; Molecular sieveReflux;
参考文献
Hatano, Manabu; Kamiya, Sho; Ishihara, Kazuaki
Chemical Communications, 2012 , vol. 48, # 76 p. 9465 - 9467
参考文献
Eliel; Anderson
Journal of the American Chemical Society, 1952 , vol. 74, p. 547
反应条件
1: 85 percent / KSCOCH3; Triton X-405 / 150 °C
2: 70 °C
View Scheme
参考文献
Bhattacharya, Apurba; Patel, Nitin C.; Vasques, Tomas; Tichkule, Ritesh; Parmar, Gaurang; Wu, Jiejun
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 565 - 567
反应条件
diethyl ether
nachfolgende Reduktion des Reaktionsprodukts mit Na2S2O4;
参考文献
Votocek; Matejka
Chemische Berichte, 1913 , vol. 46, p. 1758
反应条件
sodium hydride in tetrahydrofuran
Condensation; Heating;
参考文献
Kayaleh, Nadim E.; Gupta, Ramesh C.; Johnson, Francis
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4515 - 4522
反应条件
sodium hydroxide in ethanol
T=25°C; var. solv.; Rate constant;
参考文献
Sachweh, Volker; Langhals, Heinz
Chemische Berichte, 1986 , vol. 119, # 5 p. 1627 - 1639
