1: 2-hydroxy-5-bromo-benzoic aldehyde With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: benzyl bromide in N,N-dimethyl-formamide T=20°C; 4 h;

1: 2-hydroxy-5-bromo-benzoic aldehyde With sodium carbonate; sodium iodide in ethanol; water T=22°C; 3 h; Inert atmosphereRefluxLarge scale reaction; 2: benzyl chloride in ethanol; water Inert atmosphere;

in N,N-dimethyl-formamide

sodium iodide; potassium carbonate in water

bromine; sodium acetate; acetic acid

暂无反应条件数据

暂无反应条件数据

1: 1) Sn(OTf)2, N-ethylpiperidine / 1) THF, -78 deg C, 90 min, 2) 2 h 2: 90 percent / MeMgBr / diethyl ether; CH2Cl2 / 0.05 h / 0 °C 3: 90 percent / DMAP / CH2Cl2 / 0.17 h 4: 30percent H2O2, HCO2H / CH2Cl2 / 0.5 h / 0 °C 5: 2) 2M Na2CO3 / 1) Pd(PPh3)4 / 1) THF, 1 h, reflux, 2) 24 h, reflux 6: 80 percent / Cs2CO3 / methanol / 2 h / Ambient temperature 7: 95 percent / tetramethylguanidine / tetrahydrofuran / 1) -70 to -30 deg C, 5 h, 2) -30 deg C, 2 d, 3) RT, 15 h 8: 85 percent / H2 / (R,R)-<Rh(1,5-COD)(DIPAMP)>BF4 / methanol; CH2Cl2 / 48 h / 2250.2 Torr / Ambient temperature 9: 6M HCl / dioxane; CH2Cl2 / 0.5 h / Ambient temperature 10: hydroxybenzotriazole, N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide*HCl / CH2Cl2 / 15 h / -10 deg C to RT 11: 71 percent / HOAc / H2O / 4 h / 50 °C 12: 96 percent / Bu4NF*3H2O / dimethylformamide / 2 h / Ambient temperature 13: EDCI / CH2Cl2 / 15 h / -10 deg C to RT 14: 6M HCl / dioxane; CH2Cl2 / 0.5 h / Ambient temperature 15: aq. KHCO3 / CHCl3 / 1) RT, 2 h, 2) 50 deg C, 30 min 16: 95 percent / 1M LiOH / H2O; dioxane / 2 h / 10 °C 17: thioanisole, BrSiMe3, CF3COOH / 1 h / 0 °C View Scheme

sodium tetrahydroborate in ethanol T=0 - 20°C; 3 h;

trifluoroacetic acid T=80°C; 1 h;