2,3-二氟-4-庚基-4''-戊基-1,1':4',1''-三联苯合成路线 （共 4 条）
反应条件
sodium lauryl sulfate; sodium hydrogencarbonate; butan-1-ol; tetrakis(triphenylphosphine) palladium(0) in water; toluene Suzuki cross-coupling reaction; 6 h; Heating;
参考文献
Vashchenko, Valery; Krivoshey, Alexander; Knyazeva, Irina; Petrenko, Alexey; Goodby, John W.
Tetrahedron Letters, 2008 , vol. 49, # 9 p. 1445 - 1449
反应条件
1: 86 percent / butyl-lithium / hexane; tetrahydrofuran / -78 deg C, 2.5 h then rt. 2: 1.) phosphorus pentaoxide; 2.) hydrogen / 2.) 5percent Pd/C / 1.) pentane, rt.; 2.) pentane, rt., 4 h 3: 1.) butyl-lithium; 2.) tri-isopropyl borate; 3.) aq. sodium carbonate / 3.) tetrakis(triphenylphosphine)palladium(o) / 1.) THF/hexane, -78 deg C, 2.5 h; 2.) THF/hexane, rt.; 3.) ethanol/benzene, 23 h, reflux View Scheme
参考文献
Gray, George W.; Hird, Michael; Lacey, David; Toyne, Kenneth J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 2041 - 2054
反应条件
1: 86 percent / butyl-lithium / hexane; tetrahydrofuran / -78 deg C, 2.5 h then rt. 2: 1.) phosphorus pentaoxide; 2.) hydrogen / 2.) 5percent Pd/C / 1.) pentane, rt.; 2.) pentane, rt., 4 h 3: 1.) butyl-lithium; 2.) tri-isopropyl borate; 3.) aq. sodium carbonate / 3.) tetrakis(triphenylphosphine)palladium(o) / 1.) THF/hexane, -78 deg C, 2.5 h; 2.) THF/hexane, rt.; 3.) ethanol/benzene, 23 h, reflux View Scheme
参考文献
Gray, George W.; Hird, Michael; Lacey, David; Toyne, Kenneth J.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 2041 - 2054
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; toluene T=110°C; Suzuki coupling; 24 h;
参考文献
Januszko, Adam; Glab, Kristin L.; Kaszynski, Piotr; Patel, Kaushik; Lewis, Robert A.; Mehl, Georg H.; Wand, Michael D.
Journal of Materials Chemistry, 2006 , vol. 16, # 31 p. 3183 - 3192
