对甲基-N-甲基-N-甲氧基苯甲酰胺合成路线 （共 18 条）
反应条件
in methanol-d4 T=29.5°C; Rate constant;
参考文献
Canadian Journal of Chemistry, , vol. 69, # 5 p. 798 - 810
反应条件
in tetrahydrofuran T=0 - 20°C; 0.5 h; Yield given;
参考文献
Synthetic Communications, , vol. 29, # 8 p. 1249 - 1255
反应条件
1: p-bromophenyl bromide With iodine; magnesium in diethyl ether T=20 - 30°C; Inert atmosphere; 2: N-methoxy-N,4-dimethylbenzamide in diethyl ether T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1: 1) n-butyllithium / 1) THF, 0 deg C, 3 h; 2) THF, room temp., 2 h 2: 73 percent / tetrahydrofuran / -78 - 20 °C 3: 84 percent / 3N-aq. HCl / dioxane / 72 h / Heating View Scheme
参考文献
Turner, James A.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4744 - 4750
反应条件
1: meta-dibromobenzene With iodine; magnesium in diethyl ether T=20 - 30°C; Inert atmosphere; 2: N-methoxy-N,4-dimethylbenzamide in diethyl ether T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
in tetrahydrofuran
T=-78 - -50°C; Inert atmosphere;
参考文献
Zhang, Lei; Xie, Xiaomin; Fu, Lei; Zhang, Zhaoguo
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3434 - 3437
反应条件
1: in tetrahydrofuran
1 h;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Nippon Shinyaku Co., Ltd.
Patent: EP1400518 A1, 2004 ;
Location in patent: Page 29 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane
T=-78°C; 1.5 h; Inert atmosphere;
2: With ammonia; iodine in tetrahydrofuran; hexane; water
T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
