4-氯-N-甲氧基-N-甲基乙酰胺合成路线 （共 42 条）
反应条件
in methanol-d4 T=29.6°C; Rate constant;
参考文献
Canadian Journal of Chemistry, , vol. 69, # 5 p. 798 - 810
反应条件
in methanol-d4 T=29.6°C; Rate constant;
参考文献
Canadian Journal of Chemistry, , vol. 69, # 5 p. 798 - 810
反应条件
1: vinyl-magnesium bromide; 4-chloro-N-methoxy-N-methyl-benzamide in tetrahydrofuran 2: dimethyl amine in tetrahydrofuran
参考文献
Lee, Ki-Ho; Park, Chun-Eung; Min, Kyung-Hyun; Shin, Yong-Je; Chung, Coo-Min; Kim, Hui-Ho; Yoon, Hae-Jeoung; Won-Kim; Ryu, Eun-Ju; Shin, Yu-Jin; Nam, Hyun-Sik; Cho, Jeong-Woo; Lee, Hee-Yoon
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5567 - 5571
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
反应条件
1: Methyltriphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-15°C; 0.666667 h; 2: 4-chloro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; 20 h; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether; hexane T=20°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
反应条件
in tetrahydrofuran T=0 - 20°C; 0.2 h; Yield given;
参考文献
Lee, Na Ra; Lee, Jae In
Synthetic Communications, 1999 , vol. 29, # 8 p. 1249 - 1255
反应条件
in tetrahydrofuran Substitution;
参考文献
Piotrowski, David W.
Synlett, 1999 , # 7 p. 1091 - 1093
反应条件
1: p-bromophenyl bromide With iodine; magnesium in diethyl ether T=20 - 30°C; Inert atmosphere; 2: 4-chloro-N-methoxy-N-methyl-benzamide in diethyl ether T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1: 3-methoxy-iodobenzene With isopropylmagnesium chloride in tetrahydrofuran T=-20°C; 1 h; 2: 4-chloro-N-methoxy-N-methyl-benzamide in tetrahydrofuran T=-78 - 0°C; 3.5 h;
参考文献
Debnath, Joy; Siricilla, Shajila; Wan, Bajoie; Crick, Dean C.; Lenaerts, Anne J.; Franzblau, Scott G.; Kurosu, Michio
Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3739 - 3755
反应条件
1: n-butyl-triphenylphosphonium bromide With n-butyllithium in tetrahydrofuran; hexane T=-15°C; 2: 4-chloro-N-methoxy-N-methyl-benzamide in tetrahydrofuran; hexane T=-78 - 20°C; Wittig reaction; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether; hexane T=20°C;
参考文献
Murphy, John A.; Commeureuc, Aurelien G. J.; Snaddon, Thomas N.; McGuire, Thomas M.; Khan, Tanweer A.; Hisler, Kevin; Dewis, Mark L.; Carling, Robert
Organic Letters, 2005 , vol. 7, # 7 p. 1427 - 1429
