1: (S)-3-lt;(methylsulfonyl)oxygt;-1-pyrrolidinecarboxylic acid phenylmethyl ester With ammonia in water T=80°C; P=6000.6 Torr; 16 h; 2: acetic acid in ethyl acetate T=5°C; 0.5 h;

1: sodium azide / dimethylformamide / 2 h / 100 °C 2: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr 3: 1.0 N aq. NaOH / 2-methyl-propan-2-ol / Ambient temperature View Scheme

1: sodium azide / dimethylformamide / 2 h / 100 °C 2: H2 / Raney nickel / methanol / 21.5 h / 21.5 - 25 °C / 2585.7 Torr View Scheme

With  sodium azide in  N,N-dimethyl-formamide T=100°C; 2 h;