N-甲氧基-N-甲基-N2-{[(2-甲基-2-丙基)氧基]羰基}-L-丝氨酰胺合成路线 （共 10 条）
反应条件
4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=-15°C; 4.5 h;
参考文献
Mina, John G.; Mosely, Jackie A.; Ali, Hayder Z.; Denny, Paul W.; Steel, Patrick G.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 6 p. 1823 - 1830
反应条件
hydrogen; palladium on activated charcoal in methanol 20 h; Ambient temperature;
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide
参考文献
Panda, Gautam; Rao, N. Venugopal
Synlett, 2004 , # 4 p. 714 - 716
反应条件
1: NaOH / dioxane; H2O / 0 - 20 °C 2: N-methyl morpholine; EDCI / CH2Cl2 / 20 °C View Scheme
参考文献
Bag, Subhendu Sekhar; Jana, Subhashis; Yashmeen, Afsana; Senthilkumar; Bag, Raghunath
Chemical Communications, 2014 , vol. 50, # 4 p. 433 - 435
反应条件
1: 1.) Et3N, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / 1) CH2Cl2, 5 min; 2) CH2Cl2, 1 h 2: 73 percent / H2 / Pd-C / methanol / 20 h / Ambient temperature View Scheme
参考文献
Niel, Gilles; Roux, Florence; Maisonnasse, Ysadora; Maugras, Isabelle; Poncet, Joel; Jouin, Patrick
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1275 - 1280
反应条件
4-methyl-morpholine; isobutyl chloroformate -25 deg C bis RT;
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
1: 73 percent / s-BuMgCl / tetrahydrofuran; diethyl ether / -15 - 20 °C 2: 98 percent / LiAl(O-t-Bu)3H / ethanol / 6 h / -78 °C View Scheme
参考文献
So, Regina C.; Ndonye, Rachel; Izmirian, Douglas P.; Richardson, Stewart K.; Guerrera, Robyn L.; Howell, Amy R.
Journal of Organic Chemistry, 2004 , vol. 69, # 9 p. 3233 - 3235
反应条件
1: BF3*Et2O / acetone / 0 °C 2: LAH / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
pyridinium p-toluenesulfonate Heating17 + 9 h;
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
1: imidazole / dimethylformamide / 0.17 h / 0 °C
2: 92 percent / tetrahydrofuran / 0.17 h / 20 °C
3: 96 percent / LiAl(Ot-Bu)3H / ethanol / 0.25 h / -78 °C
4: 97 percent / aq. HCl / methanol / 0.25 h / 20 °C
5: 58 percent / (N,N'-Mes2-imidazolidin-2-yl)Ru=CHPh(PCy3)Cl2 / CH2Cl2 / 2 h / Heating
View Scheme
参考文献
Mina, John G.; Mosely, Jackie A.; Ali, Hayder Z.; Denny, Paul W.; Steel, Patrick G.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 6 p. 1823 - 1830
