(S)-3-N-Boc-4-(甲氧基-甲基-氨基甲酰胺基)-2,2-二甲基噁唑烷合成路线 （共 6 条）
反应条件
pyridinium p-toluenesulfonate Heating17 + 9 h;
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
反应条件
1: N-methyl morpholine; EDCI / CH2Cl2 / 20 °C 2: BF3*Et2O / acetone / 0 °C View Scheme
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
1: NaOH / dioxane; H2O / 0 - 20 °C 2: N-methyl morpholine; EDCI / CH2Cl2 / 20 °C 3: BF3*Et2O / acetone / 0 °C View Scheme
参考文献
Wang, Jiashi; Swidorski, Jacob J.; Sydorenko, Nadiya; Hsung, Richard P.; Coverdale, Heather A.; Kuyava, Jennifer M.; Liu, Jia
Heterocycles, 2006 , vol. 70, p. 423 - 459
反应条件
lithium aluminium tetrahydride in diethyl ether T=5°C; 1.5 h;
参考文献
Bold, Guido; Allmendinger, Thomas; Herold, Peter; Moesch, Luzia; Schaer, Hans-Peter; et al.
Helvetica Chimica Acta, 1992 , vol. 75, # 3 p. 865 - 882
反应条件
1: (4S)-2,2-Dimethyl-4-(N-methoxy-N-methylcarbamoyl)oxazolidin-3-carbonsaeure-(tert-butyl)ester With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: (1-Diazo-2-oxo-propyl)-phosphonic acid dimethyl ester in methanol
T=0°C; 0.5 h; Inert atmosphere;
3: With potassium carbonate in methanol
T=20°C; 15 h; Inert atmosphere;
参考文献
Temperini, Andrea; Capperucci, Antonella; Degl'Innocenti, Alessandro; Terlizzi, Raffaella; Tiecco, Marcello
Tetrahedron Letters, 2010 , vol. 51, # 31 p. 4121 - 4124
