3-羟基-4-戊酸叔丁酯合成路线 （共 14 条）
反应条件
1: acetic acid tert-butyl ester With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 1 h; 2: acrolein in tetrahydrofuran; hexane 1 h; Further stages.;
参考文献
Bauer, Matthias; Maier, Martin E
Organic letters, 2002 , vol. 4, # 13 p. 2205 - 2208
反应条件
RuCl2(tricyclohexylphosphine)2(benzylidene) in dichloromethane T=65°C; 18 h; Inert atmosphere;
参考文献
Rempex Pharmaceuticals, Inc.
Patent: US2012/40932 A1, 2012 ;
Location in patent: Page/Page column 41 ;
US 20120040932 A1
反应条件
in tetrahydrofuran T=-78°C; 0.0833333 h;
参考文献
Vrielynck, Sara; Vandewalle, Maurits; Garcia, Ana M.; Mascarenas, Jose L.; Mourino, Antonio
Tetrahedron Letters, 1995 , vol. 36, # 49 p. 9023 - 9026
反应条件
Amano PS-D lipase in pentane T=35°C; 3 h;
参考文献
Lu, Chong-Dao; Zakarian, Armen
Organic Letters, 2007 , vol. 9, # 16 p. 3161 - 3163
反应条件
Amano PS Lipase in pentane 45 h; Heating; Title compound not separated from byproducts;
参考文献
Gonzalez-Garcia, Eva; Helaine, Virgil; Klein, Gerard; Schuermann, Melanie; Sprenger, Georg A.; Fessner, Wolf-Dieter; Reymond, Jean-Louis
Chemistry - A European Journal, 2003 , vol. 9, # 4 p. 893 - 899
反应条件
N-((R)-N-diphenylmethyl-2-amino-2-phenylethyl)-(S)-prolinol; chloro-trimethyl-silane; bromoacetic acid tert-butyl ester; zinc in tetrahydrofuran 2.5 h; Refluxkinetic resolution; KineticsReactivity; Reagent/catalystTime; optical yield given as percent eeenantioselective reaction;
参考文献
Min, Hee Lee; Eui, Ta Choi; Kim, Dajung; Yoon, Min Lee; Yong, Sun Park
European Journal of Organic Chemistry, 2008 , # 33 p. 5630 - 5637
反应条件
Amano Lipase PS in pentane T=30°C; 16 h; Inert atmosphereMolecular sieve; optical yield given as percent eeenantioselective reaction;
参考文献
Tan, Choon-Hong; Holmes, Andrew B.
Chemistry - A European Journal, 2001 , vol. 7, # 9 p. 1845 - 1854
反应条件
Amano PS-D lipase in pentane T=35°C; 3 h;
参考文献
Lu, Chong-Dao; Zakarian, Armen
Organic Letters, 2007 , vol. 9, # 16 p. 3161 - 3163
反应条件
Pseudomonas cepacia lipase immobilized on ceramic particles in pentane T=20°C; 19 h;
参考文献
Pollini, Gian Piero; De Risi, Carmela; Lumento, Flavio; Marchetti, Paolo; Zanirato, Vinicio
Synlett, 2005 , # 1 art. no. G40004ST, p. 164 - 166
反应条件
Amano PS Lipase in pentane 45 h; Heating; Title compound not separated from byproducts;
参考文献
Gonzalez-Garcia, Eva; Helaine, Virgil; Klein, Gerard; Schuermann, Melanie; Sprenger, Georg A.; Fessner, Wolf-Dieter; Reymond, Jean-Louis
Chemistry - A European Journal, 2003 , vol. 9, # 4 p. 893 - 899
