4-(三氟甲基磺酰氧基)-3-环己烯羧酸乙酯合成路线 （共 7 条）
反应条件
1: 4-ketocyclohexanecarboxylic acid ethyl ester With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 1 h; 2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=-78 - 20°C; 12.5 h;
参考文献
US2011/245237 A1, ;
Page/Page column 19 ;
反应条件
1: trifluoromethylsulfonic anhydride With pyridine in toluene T=15 - 25°C; 0.5 h; 2: 4-ketocyclohexanecarboxylic acid ethyl ester in toluene T=40°C; 2 - 27 h; Product distribution / selectivity;
参考文献
EP1553082 A1, ;
Page/Page column 16-18 ;
反应条件
1: 4-ketocyclohexanecarboxylic acid ethyl ester With n-butyllithium; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.25 h; 2: N-phenyl-1,1,1-trifluoromethanesulfonamide in tetrahydrofuran; hexane T=-78 - 0°C; 1 h;
参考文献
EP1577302 A1, ;
Page/Page column 125 ;
反应条件
1: 4-ketocyclohexanecarboxylic acid ethyl ester With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 1 h; 2: N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide in tetrahydrofuran T=20°C; 12 h;
参考文献
WO2007/81569 A2, ;
Page/Page column 95 ;
反应条件
trifluorormethanesulfonic acid in dichloromethane T=25°C;
参考文献
EP1371646 A1, ;
Page 40 ;
反应条件
in tetrahydrofuran T=-78°C;
参考文献
WO2007/81569 A2, ;
Page/Page column 95 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in 1,4-dioxane T=90°C; 18 h; Inert atmosphere;
参考文献
US2011/251183 A1, ;
Page/Page column 18 ;
US 20110251183 A1
