4-氯-2-碘-6-硝基苯胺合成路线 （共 9 条）
反应条件
iodine; silver sulphate in ethanol T=20°C; 36 h;
参考文献
Dohle, Wolfgang; Staubitz, Anne; Knochel, Paul
Chemistry - A European Journal, 2003 , vol. 9, # 21 p. 5323 - 5331
反应条件
1: hydrochloric acid 2: p-toluenesulfonic acid dichloroamide; glacial acetic acid; sodium iodide View Scheme
参考文献
Bradfield; Orton; Roberts
Journal of the Chemical Society, 1928 , p. 783
参考文献
Bradfield; Orton; Roberts
Journal of the Chemical Society, 1928 , p. 783
反应条件
hydrogen; Pb-CaCO3 in tetrahydrofuran
参考文献
Novartis Consumer Health S.A.
Patent: US5877340 A1, 1999 ;
反应条件
in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; ethanol
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
1: 1.) conc. H2SO4, 2.) sodium nitrite / ethanol / 1.) EtOH, reflux, 2.) reflux, 1 h 2: 81 percent / Fe, HOAc / ethanol / 6 h / Heating View Scheme
参考文献
Leeson, Paul D.; Baker, Raymond; Carling, Robert W.; Curtis, Neil R.; Moore, Kevin W.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1243 - 1252
反应条件
n-Pentyl nitrite; ethanol Diazotization;
参考文献
Leeson, Paul D.; Baker, Raymond; Carling, Robert W.; Curtis, Neil R.; Moore, Kevin W.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1243 - 1252
参考文献
Bradfield; Orton; Roberts
Journal of the Chemical Society, 1928 , p. 783
反应条件
1: 1.) conc. H2SO4, 2.) sodium nitrite / ethanol / 1.) EtOH, reflux, 2.) reflux, 1 h
2: 81 percent / Fe, HOAc / ethanol / 6 h / Heating
View Scheme
参考文献
Leeson, Paul D.; Baker, Raymond; Carling, Robert W.; Curtis, Neil R.; Moore, Kevin W.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 4 p. 1243 - 1252
