1-(4-硝基苯基)丙-2-烯-1-醇合成路线 （共 9 条）
反应条件
in tetrahydrofuran T=-50°C; 0.666667 h;
参考文献
Hu, Longqin
Patent: US2004/214798 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
1: in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: With water; ammonium chloride in tetrahydrofuran T=20°C;
参考文献
Bouziane, Asmae; Carboni, Bertrand; Bruneau, Christian; Carreaux, Francois; Renaud, Jean-Luc
Tetrahedron, 2008 , vol. 64, # 51 p. 11745 - 11750
反应条件
tris(acetonitrile)(η5-2,4-cyclopentadien-1-yl)ruthenium(1+) hexafluorophosphate(1-); potassium carbonate; 3,4,5-trimethoxyphenylboronic acid in acetonitrile T=20°C; 24 h; Inert atmosphere; regioselective reaction;
参考文献
Bouziane, Asmae; Helou, Marion; Carboni, Bertrand; Carreaux, Francois; Demerseman, Bernard; Bruneau, Christian; Renaud, Jean-Luc
Chemistry - A European Journal, 2008 , vol. 14, # 18 p. 5630 - 5637
参考文献
Yin, Jiandong; Gallis, Christina E.; Chisholm, John D.
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 7054 - 7057
反应条件
1.1: 44 percent / Ti(O-iPr)4; (+)-diisopropyl tartrate; tert-butyl hydroperoxide / molecular sieves 4 Angstroem / CH2Cl2 / 14 h / -20 °C 2.1: CH2Cl2 / 2 h / 0 - 25 °C 2.2: 90 percent / potassium carbonate / methanol; H2O / 18 h / 0 - 25 °C 3.1: 69 percent / sodium hydroxide; tert-butyl hypochlorite; potassium osmate / ethyldiisopropylamine / propan-1-ol; H2O / 3 h / 25 °C 4.1: NaOH / methanol; H2O / 25 °C 4.2: 78 percent / 3 h / 90 °C View Scheme
参考文献
George, Shyla; Narina, Srinivasarao V.; Sudalai, Arumugam
Tetrahedron, 2006 , vol. 62, # 43 p. 10202 - 10207
反应条件
1: With diborane in tetrahydrofuran T=0°C; 20 h; 2: With sodium hydroxide; dihydrogen peroxide T=0°C; 0.5 h;
参考文献
Hu, Longqin
Patent: US2004/214798 A1, 2004 ;
Location in patent: Page 12; 13 ;
反应条件
[Cp*Ru(CNCH3)3]+PF6-; potassium carbonate in acetonitrile
1 h; Inert atmosphereReflux;
参考文献
Bouziane, Asmae; Carboni, Bertrand; Bruneau, Christian; Carreaux, Francois; Renaud, Jean-Luc
Tetrahedron, 2008 , vol. 64, # 51 p. 11745 - 11750
反应条件
1.1: B2H6 / tetrahydrofuran / 20 h / 0 °C
1.2: 82 percent / aq. NaOH; H2O2 / 0.5 h / 0 °C
2.1: 95 percent / imidazole / dimethylformamide / 1.2 h / -30 - -20 °C
3.1: 97 percent / triphenylphosphine; hydrazoic acid; diethyl azodicarboxylate / tetrahydrofuran; benzene / 2 h / 20 °C
4.1: 70 percent / propane-1,3-dithiol; Et3N / methanol / 12 h / 20 °C
5.1: 82 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
View Scheme
参考文献
Jiang, Yongying; Han, Jiye; Yu, Chengzhi; Vass, Simon O.; Searle, Peter F.; Browne, Patrick; Knox, Richard J.; Hu, Longqin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4333 - 4343
反应条件
sulfuric acid; nitrogen in tetrahydrofuran; water; toluene; acetonitrile
参考文献
Trustees of The University of Pennsylvania
Patent: US5399790 A1, 1995 ;
