N-Boc-4-哌啶甲醇合成路线 （共 71 条）
反应条件
sodium carbonate in 1,4-dioxane; diethyl ether; ethyl acetate
参考文献
Eli Lilly and Company
Patent: US6303627 B1, 2001 ;
US 6303627 B1
反应条件
sodium hydroxide; sodium tetrahydroborate; triethylamine in tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane
反应条件
1: 92 percent / aq. NaOH, Et3N / dioxane / 20 h / Ambient temperature 2: BH3*THF / tetrahydrofuran / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421
反应条件
1: 98 percent / Et3N; DMAP / CH2Cl2 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 9 p. 2233 - 2239
参考文献
US2004/2504 A1, ;
Page/Page column 19; 39 ;
US 20040002504 A1
反应条件
in tetrahydrofuran; hexane
参考文献
US6265434 B1, ;
US 6265434 B1
反应条件
1: hydrogen / palladium 10 on activated carbon / ethanol; water / 15 h / 23 °C / 760.05 Torr 2: hydrogen; sodium hydroxide / rhodium contaminated with carbon / water / 21 h / 60 - 70 °C / 7500.75 - 9750.98 Torr View Scheme
参考文献
WO2012/135570 A1, ;
WO 2012/135570 A1
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 42, # 13 p. 1289 - 1300
反应条件
1: 40 percent / Dess-Martin reagent / CH2Cl2 / 1 h / 20 °C 2: TFA / 20 °C View Scheme
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
tetrachloromethane in dichloromethane T=20°C;
参考文献
WO2006/20415 A1, ;
Page/Page column 61; 62 ;
WO 2006/020415 A1
