1: 2-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 3.166 h; 2: carbon dioxide in tetrahydrofuran 3: With hydrogenchloride in tetrahydrofuran; water T=0°C; pH=~ 2.5;
参考文献
AMGEN INC.
Patent: WO2006/12374 A1, 2006 ;
Location in patent: Page/Page column 149-150 ;
WO 2006/012374 A1
Langham; Brewster; Gilman
Journal of the American Chemical Society, 1941 , vol. 63, p. 545,548
Full Text Show Details
Gilman; Langham; Moore
Journal of the American Chemical Society, 1940 , vol. 62, p. 2327,2333
Langham; Brewster; Gilman
Journal of the American Chemical Society, 1941 , vol. 63, p. 545,548
Full Text Show Details
Gilman; Langham; Moore
Journal of the American Chemical Society, 1940 , vol. 62, p. 2327,2333
1: 2-bromo-2-phenyl-1-ethene With lithium chloride; zinc 2: carbon dioxide With lithium chloride in N,N-dimethyl-formamide T=50°C; P=760.051 Torr; 24 h; 3: With hydrogenchloride; water in N,N-dimethyl-formamide
1: With copper(l) iodide; cesium fluoride in N,N-dimethyl-formamide T=90°C; P=760.051 Torr; 10 h; 2: With hydrogenchloride; water in N,N-dimethyl-formamide
