2-氨基-2-甲基-1-丙醇合成路线 （共 271 条）
反应条件
1: salicylic acid With pyridine; 2,4,6-trichloro-1,3,5-triazine in dichloromethane T=0°C; 0.25 h; 2: 2-amino-2-methyl-propan-1-ol With indium in dichloromethane T=20°C; 30 h;
参考文献
Kangani, Cyrous O.; Day, Billy W.
Tetrahedron Letters, 2009 , vol. 50, # 38 p. 5332 - 5335
反应条件
tetrabutylammomium bromide; potassium carbonate in N,N-dimethyl-formamide T=160°C; 0.25 h; Microwave irradiation;
参考文献
Djurendic, Evgenija; Vujaskovic, Sanja Dojcinovic; Sakac, Marija; Ajdukovic, Jovana; Gakovic, Andrea; Kojic, Vesna; Bogdanovic, Gordana; Klisuric, Olivera; Gasi, Katarina Penov
Arkivoc, 2011 , vol. 2011, # 2 art. no. 37175
反应条件
zinc(II) chloride 60 h; Irradiation;
参考文献
Clarke, David S.; Wood, Robin
Synthetic Communications, 1996 , vol. 26, # 7 p. 1335 - 1340
反应条件
sodium T=150°C; 2 h;
参考文献
Djurendic, Evgenija; Vujaskovic, Sanja Dojcinovic; Sakac, Marija; Ajdukovic, Jovana; Gakovic, Andrea; Kojic, Vesna; Bogdanovic, Gordana; Klisuric, Olivera; Gasi, Katarina Penov
Arkivoc, 2011 , vol. 2011, # 2 art. no. 37175
反应条件
water; sodium carbonate in dichloromethane Acylation;
参考文献
Elliott, Mark C.; Kruisvvijk, Elbertus
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 21 p. 3157 - 3166
反应条件
1: (R)-(+)-1-(3-chlorophenyl)-2-hydroxypropan-1-one With trifluoromethylsulfonic anhydride; N,N,N',N'-tetra-methylnaphthalene-1,8-diamine in dichloromethane T=-50 - 0°C; 1 h; 2: 2-amino-2-methyl-propan-1-ol in dichloromethane; acetonitrile T=-10 - 0°C; 4 h;
参考文献
RESEARCH TRIANGLE INSTITUTE; CARROLL, F. Ivy; BLOUGH, Bruce E.; NAVARRO, Hernan A.; MASCARELLA, S. Wayne; MURESAN, Ana Zamfira; DAMAJ, M. Imad; LUKAS, Ronald J.
Patent: WO2011/146821 A2, 2011 ;
Location in patent: Page/Page column 54 ;
WO 2011/146821 A2
反应条件
in dichloromethane T=-40 - 0°C; cyclocondensation;
参考文献
Fang, Qun K.; Han, Zhengxu; Grover, Paul; Kessler, Donald; Senanayake, Chris H.; Wald, Stephen A.
Tetrahedron Asymmetry, 2000 , vol. 11, # 18 p. 3659 - 3663
反应条件
in chloroform T=80°C; 168 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 26 p. 9255 - 9261
参考文献
Booth, Brian L.; Jibodu, Kehinde O.; Proenca, M. Fernanda J. R. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 5 p. 1067 - 1073
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=0°C; 0.5 h;
参考文献
Kangani, Cyrous O.; Kelley, David E.
Tetrahedron Letters, 2005 , vol. 46, # 51 p. 8917 - 8920
