2,2,2,2-四氟苯乙酮合成路线 （共 4 条）
反应条件
2,6-dimethylpyridine; oxoammonium salt in dichloromethane T=20°C; Sealed tube;
参考文献
Kelly, Christopher B.; Mercadante, Michael A.; Hamlin, Trevor A.; Fletcher, Madison H.; Leadbeater, Nicholas E.
Journal of Organic Chemistry, 2012 , vol. 77, # 18 p. 8131 - 8141
反应条件
1: (trifluoromethyl)-trimethylsilane With silver monofluoride T=20°C; 2 h; 2: 2-fluoro-benzoyl chloride With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 48 h; Further stages.;
参考文献
Kremlev, Mikhail M.; Mushta, Aleksej I.; Tyrra, Wieland; Naumann, Dieter; Fischer, Hendrik T.M.; Yagupolskii, Yurii L.
Journal of Fluorine Chemistry, 2007 , vol. 128, # 11 p. 1385 - 1389
反应条件
1: 46 percent / Zn / pyridine / 4 h / 1520 - 2660 Torr 2: 65 percent / potassium dichromate, concd. H2SO4 / acetic acid; H2O / 72 h View Scheme
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 108, # 4 p. 147 - 160
反应条件
1: 66 percent / Et3N / acetonitrile / 18 h / Heating
2: 100 percent / LiOH / tetrahydrofuran; H2O / 20 °C
View Scheme
参考文献
Owton
Tetrahedron Letters, 2003 , vol. 44, # 38 p. 7147 - 7149
