(4R-Cis)-6-羟甲基-2,2-二甲基-1,3-二氧六环-4-乙酸叔丁酯合成路线 （共 28 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate T=31 - 33°C; P=7600 Torr; 5 h;
参考文献
Synthesis, , # 8 p. 1014 - 1018
反应条件
potassium carbonate in methanol; water
反应条件
sodium tetrahydroborate in methanol T=0°C; 2 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 68, # 1 p. 364 - 372
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=0°C; 3 h;
参考文献
Tetrahedron Letters, , vol. 31, # 18 p. 2545 - 2548
反应条件
hydrogenchloride; sodium borohydride; ammonium chloride in tetrahydrofuran; methanol
参考文献
US5214197 A1, ;
US 5214197 A
反应条件
sodium ethanolate in ethanol T=20°C; 15 h;
参考文献
Synlett, , # 10 p. 1523 - 1525
反应条件
1: 100 percent / LDA / tetrahydrofuran / 1.75 h / -70 - -15 °C 2: 1). Et3B; 2.) NaBH4, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C 3: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 4: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 18 p. 2545 - 2548
反应条件
1: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 2: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 18 p. 2545 - 2548
反应条件
1: 1). Et3B; 2.) NaBH4, MeOH / 1.) THF, 23 deg C, 15 min; 2.) -70 deg C 2: 70 percent / p-toluenesulfonic acid / acetone / 2 h / 23 °C 3: 80 percent / Bu4NF / tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 18 p. 2545 - 2548
反应条件
1: 85 percent / sodium metaperiodate, water / diethyl ether / 3 h / Ambient temperature 2: 83 percent / sodium borohydride / methanol / 2 h / 0 °C View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 68, # 1 p. 364 - 372
