乙基[二(2,2,2-三氟乙氧基)氧膦基]乙酸合成路线 （共 9 条）
反应条件
1: Bis(2,2,2-trifluoroethyl) phosphonate With sodium hydride in tetrahydrofuran T=-42°C; Metallation; 2: ethyl bromoacetate in tetrahydrofuran T=20°C; Michaelis-Becker reaction; 5 h;
参考文献
Ciszewski, Gregory M.; Jackson, John A.
Organic Preparations and Procedures International, 1999 , vol. 31, # 2 p. 240 - 243
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=20°C; 16 h; Inert atmosphereCooling with ice;
参考文献
Messik, Frauke; Oberthuer, Markus
Synthesis (Germany), 2013 , vol. 45, # 2 art. no. SS-2012-T0771-PSP, p. 167 - 170
反应条件
1: n-BuLi, HMDS / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C 2: aq. HCl View Scheme
参考文献
Synthetic Communications, , vol. 21, # 22 p. 2391 - 2396
反应条件
triethylamine; lithium bromide in tetrahydrofuran T=25°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
反应条件
triethylamine; lithium bromide in tetrahydrofuran T=25°C; 24 h; other ketones; Product distribution;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
反应条件
triethylamine; lithium bromide in tetrahydrofuran T=25°C; 24 h;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
反应条件
triethylamine; lithium bromide in tetrahydrofuran T=25°C; 24 h;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
反应条件
triethylamine; lithium bromide in tetrahydrofuran
T=25°C; 24 h;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
反应条件
triethylamine; lithium bromide in tetrahydrofuran
T=25°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Rathke, Michael W.; Bouhlel, Ezzeddine
Synthetic Communications, 1990 , vol. 20, # 6 p. 869 - 875
