[(2R,3S,4S,5R)-5-(4-氨基-2-氧代-嘧啶-1-基)-3,4-二羟基-四氢呋喃-2-基]甲氧基-[[3-(鲸蜡基硫代)-2-棕榈酰氧基-丙氧基]-羟基-氧代-鏻基]氧基-次磷酸二钠合成路线 （共 5 条）
反应条件
1: pyridine / 24 h / Heating 2: 82.4 percent / pyridine / benzene / 70 - 80 °C 3: BF3-MeOH / CH2Cl2 / 1 h / 0 °C 4: 56 percent / POCl3, triethylamine / hexane; toluene / Ambient temperature 5: 25 percent / pyridine / 240 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1380 - 1386
反应条件
1: 98 percent / 1 N KOH / methanol / 48 h / Ambient temperature 2: pyridine / 24 h / Heating 3: 82.4 percent / pyridine / benzene / 70 - 80 °C 4: BF3-MeOH / CH2Cl2 / 1 h / 0 °C 5: 56 percent / POCl3, triethylamine / hexane; toluene / Ambient temperature 6: 25 percent / pyridine / 240 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1380 - 1386
反应条件
1: 82.4 percent / pyridine / benzene / 70 - 80 °C 2: BF3-MeOH / CH2Cl2 / 1 h / 0 °C 3: 56 percent / POCl3, triethylamine / hexane; toluene / Ambient temperature 4: 25 percent / pyridine / 240 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1380 - 1386
反应条件
1: 93.2 percent / pyridine / toluene / 24 h / Ambient temperature 2: 60 percent / AcOH, tetrabutylammonium fluoride / tetrahydrofuran / 6 h / Ambient temperature 3: 56 percent / POCl3, triethylamine / hexane; toluene / Ambient temperature 4: 25 percent / pyridine / 240 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1380 - 1386
反应条件
1: 56 percent / POCl3, triethylamine / hexane; toluene / Ambient temperature 2: 25 percent / pyridine / 240 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1380 - 1386
