5beta-孕甾烷-3,20-二酮合成路线 （共 54 条）
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Reflux 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 - 20 °C 2.2: 20 °C 3.1: 2 h 4.1: tri-n-butyl-tin hydride; 1,1'-azobis (cyclohexanecarbonitrile) / toluene / 4 h / Reflux; Inert atmosphere 5.1: hydrogenchloride; water / 0.25 h View Scheme
参考文献
Steroids, , vol. 77, # 3 p. 282 - 287
反应条件
1: potassium hydroxide; oxygen; Food Red No. 105 / methanol / 6 h / 0 °C / |Irradiation 2: Jone's reagent / acetone / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10662 - 10673
反应条件
1: triethylamine; 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 5 h / 20 °C 2: pyridine; copper diacetate; lead(IV) tetraacetate / benzene / 12 h / 90 °C / |Inert atmosphere 3: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C 4: HIO4*2H2O / tetrahydrofuran / 5 h / 0 - 20 °C 5: potassium hydroxide; oxygen; Food Red No. 105 / methanol / 6 h / 0 °C / |Irradiation 6: Jone's reagent / acetone / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10662 - 10673
反应条件
1: pyridine; copper diacetate; lead(IV) tetraacetate / benzene / 12 h / 90 °C / |Inert atmosphere 2: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C 3: HIO4*2H2O / tetrahydrofuran / 5 h / 0 - 20 °C 4: potassium hydroxide; oxygen; Food Red No. 105 / methanol / 6 h / 0 °C / |Irradiation 5: Jone's reagent / acetone / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10662 - 10673
反应条件
1: 3-chloro-benzenecarboperoxoic acid; sodium hydrogencarbonate / dichloromethane / 5 h / 0 - 20 °C 2: HIO4*2H2O / tetrahydrofuran / 5 h / 0 - 20 °C 3: potassium hydroxide; oxygen; Food Red No. 105 / methanol / 6 h / 0 °C / |Irradiation 4: Jone's reagent / acetone / 0.25 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 23 p. 10662 - 10673
反应条件
formic acid; ozone; zinc 1) CH2Cl2, -78 degC, 15 min; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 25, # 17 p. 1765 - 1768
反应条件
nicotinamide adenine dinucleotide in phosphate buffer T=50°C; pH=7.8; 1 h; Enzyme kinetics;
参考文献
Planta Medica, , vol. 73, # 7 p. 704 - 710
反应条件
2: 1) N,N-carbonyldiimidazole / 1) THF, 25 degC, 5 h; 2) THF, irradiation 3: 1) O3; 2) Zn, HCOOH / 1) CH2Cl2, -78 degC, 15 min View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 17 p. 1765 - 1768
反应条件
G6P; glucose-6-phosphate-dehydrogenase; nicotinamide adenine dinucleotide phosphate T=30°C; 3 h; Enzyme kinetics;
参考文献
Phytochemistry, , vol. 67, # 3 p. 225 - 231
参考文献
Journal of the American Chemical Society, , vol. 64, p. 213,214
