5beta-孕甾烷-3,20-二酮合成路线 （共 54 条）
反应条件
tetrachloromethane; chlorine unter Kuehlung und Erhitzen des Reaktionsprodukts mit Chinolin auf 150-160grad;
参考文献
Butenandt; Schmidt
Chemische Berichte, 1934 , vol. 67, p. 1901,1904
反应条件
Erhitzen des Reaktionsprodukts mit Chinolin auf 150-160grad;
参考文献
Schering A.G.
Patent: US2153700 , 1935 ;
Full Text Show Details
Schering A.G.
Patent: DE672896 , 1934 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 24, p. 500
反应条件
1: platinum; ethanol ether-mixture / Hydrogenation 2: sodium View Scheme
参考文献
Butenandt; Mueller
Chemische Berichte, 1938 , vol. 71, p. 191,196
反应条件
recombinant human aldo-keto reductase 1C3; NADPH in methanol T=37°C; pH=7; 1.5 h; aq. phosphate bufferEnzymatic reaction; stereospecific reaction;
参考文献
Jin, Yi; Mesaros, A. Clementina; Blair, Ian A.; Penning, Trevor M.
Biochemical Journal, 2011 , vol. 437, # 1 p. 53 - 61
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Jin, Yi; Mesaros, A. Clementina; Blair, Ian A.; Penning, Trevor M.
Biochemical Journal, 2011 , vol. 437, # 1 p. 53 - 61
反应条件
potassium tri-sec-butyl-borohydride in tetrahydrofuran T=22°C; 65 h; var. time, amount of reagent; Product distribution;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 21 p. 1239 - 1240
反应条件
1: With sodium tetrahydroborate in ethanol T=50°C; 0.166667 h; 2: With water in ethanol
参考文献
WO2009/108804 A2, ;
Page/Page column 126-127 ;
反应条件
pyridine; sodium tetrahydroborate; sodium hydroxide in methanol; water Cooling with ice;
参考文献
Kapras, Vojtech; Slavickova, Alena; Stastna, Eva; Vyklicky Jr., Ladislav; Vales, Karel; Chodounska, Hana
Steroids, 2012 , vol. 77, # 3 p. 282 - 287
反应条件
recombinant human aldo-keto reductase 1C3; NADPH in methanol T=37°C; pH=7; 1.5 h; aq. phosphate bufferEnzymatic reaction; stereospecific reaction;
参考文献
Jin, Yi; Mesaros, A. Clementina; Blair, Ian A.; Penning, Trevor M.
Biochemical Journal, 2011 , vol. 437, # 1 p. 53 - 61
