2-氯-4,5-二氟苯甲酸甲酯合成路线 (共 5 条)
反应条件
sulfuric acid T=60°C; 48 h;
参考文献
PLEXXIKON, INC.
Patent: WO2008/80001 A2, 2008 ;
Location in patent: Page/Page column 76 ;
参考文献
Bayer Schering Pharma Aktiengesellschaft
Patent: EP1897885 A1, 2008 ;
反应条件
caesium carbonate in acetone
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US6525052 B2, 2003 ;
反应条件
in methanol; toluene T=25°C;
参考文献
BRISTOL-MYERS SQUIBB PHARMA COMPANY
Patent: WO2005/51954 A2, 2005 ;
Location in patent: Page/Page column 34 ;
WO 2005/051954 A2
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 4 h; 2: With water; sodium sulfate in tetrahydrofuran 0.5 h;
参考文献
WO2008/80001 A2, ;
Page/Page column 76-77 ;