4-吡咯烷-1-苯甲酸甲酯合成路线 （共 9 条）
反应条件
1: 4-Fluorobenzoic acid methyl ester With cesium fluoride in N,N-dimethyl-formamide 0.166667 h; Inert atmosphere; 2: 1-(trimethylsilyl)pyrrolidine in N,N-dimethyl-formamide T=60°C; 110 h;
参考文献
Zylum Beteiligungsgesellschaft mbH and Co. Patente II KG
Patent: US2012/142937 A1, 2012 ;
Location in patent: Page/Page column 6 ;
反应条件
caesium carbonate; tris-(dibenzylideneacetone)dipalladium(0) in toluene
参考文献
Quibell, Martin; Taylor, Steven; Grabowska, Urszula; Nilsson, Magnus; Morrison, Veronique
Patent: US2003/186962 A1, 2003 ;
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; triethylamine; bis[2-(diphenylphosphino)phenyl] ether in toluene T=20°C; Inert atmosphereReflux;
参考文献
Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W.; Maxwell, Aoife C.; Maytum, Hannah C.; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 1766 - 1774
反应条件
cesium fluoride in N,N-dimethyl-formamide T=60°C; 110 h; Inert atmosphere;
参考文献
Dehe, Daniel; Munstein, Isabel; Reis, Andreas; Thiel, Werner R.
Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1151 - 1154
反应条件
potassium carbonate in water T=100°C; 1 h; Microwave irradiation;
参考文献
Li, Hong Bo; Liang, Wu; Liu, Lang; Chen, Kai; Wu, Yi
Chinese Chemical Letters, 2011 , vol. 22, # 3 p. 276 - 279
反应条件
1: thionyl chloride / -10 - 20 °C 2: potassium carbonate; tBuNH2·BH3 / 1,4-dioxane; water / 48 h / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 19 p. 8524 - 8537,14
反应条件
tBuNH2·BH3; potassium carbonate in 1,4-dioxane; water 48 h; Reflux;
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
water; sodium hydroxide in methanol Reflux;
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
1: sodium hydroxide; water / methanol / |Reflux
2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C
View Scheme
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
