(S)-(-)-2-氨基-1,1,2-三苯乙醇合成路线 (共 8 条)
反应条件
in diethyl ether Cooling with iceReflux;
参考文献
Kristensen, Tor E.; Vestli, Kristian; Hansen, Finn K.; Hansen, Tore
European Journal of Organic Chemistry, 2009 , # 30 p. 5185 - 5191
反应条件
in diethyl ether T=0 - 20°C;
参考文献
Dragoli; Burdett; Ellman
Journal of the American Chemical Society, 2001 , vol. 123, # 41 p. 10127 - 10128
反应条件
1: bromobenzene With iodine; magnesium in diethyl ether Heating; 2: methyl (2S)-amino(phenyl)acetate in diethyl ether Grignard reaction; Heating;
参考文献
Mueller, Simona; Afraz, Marcel Cyrus; De Gelder, Rene; Ariaans, Gerry J. A.; Kaptein, Bernard; Broxterman, Quirinus B.; Bruggink, Alle
European Journal of Organic Chemistry, 2005 , # 6 p. 1082 - 1096
反应条件
1: SOCl2 2: tetrahydrofuran View Scheme
参考文献
Organic Letters, , vol. 8, # 11 p. 2277 - 2280
反应条件
in tetrahydrofuran; diethyl ether 18 h; Ambient temperature;
参考文献
Journal of the American Chemical Society, , vol. 120, # 30 p. 7429 - 7438
参考文献
Weber, Edwin; Reutel, Christiane; Foces-Foces, Concepcion; Llamas-Saiz, Antonio L.
Journal of Physical Organic Chemistry, 1995 , vol. 8, p. 159 - 170
反应条件
n-butyllithium; hydroxylammonium acetate 1.) hexane, THF, HMPA, -78 deg C, 2.) EtOH; Multistep reaction;
参考文献
Synthetic Communications, , vol. 18, # 11 p. 1291 - 1298
参考文献
McKenzie; Wills
Journal of the Chemical Society, 1925 , vol. 127, p. 284