1: With trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran T=20°C; 0.666667 h; Inert atmospherelarge scale reaction; 2: With sodium hydroxide in tetrahydrofuran; water pH=12;

triethylamine; sodium iodide in acetonitrile 4 h; Heating;

1: 29 percent / K2CO3 / dimethylformamide / 4 h / 60 °C 2: 51 percent / NaI, Et3N / acetonitrile / 4 h / Heating View Scheme

potassium carbonate; sodium iodide in acetonitrile 6 h; Reflux;