7-(4-溴丁氧基)-3,4-二氢-2(1H)-喹啉酮合成路线 （共 15 条）
反应条件
1: 7-Hydroxy-3,4-dihydro-1H-quinolin-2-one With potassium carbonate in water; acetone T=20°C; 1 h; 2: 1,4-dibromo-butane in water; acetone T=20°C; 16 h;
参考文献
Asian Journal of Chemistry, , vol. 23, # 4 p. 1655 - 1660
反应条件
sodium hydroxide in isobutyramide T=36 - 40°C; 4 h; Product distribution / selectivity;
参考文献
US2006/258869 A1, ;
Page/Page column 3-5 ;
反应条件
1: 7-Hydroxy-3,4-dihydro-1H-quinolin-2-one With sodium hydroxide in isopropyl alcohol T=25 - 30°C; 0.5 h; 2: 1,4-dibromo-butane With tetrabutylammomium bromide in isopropyl alcohol T=80 - 85°C; 3 h; Product distribution / selectivity;
参考文献
WO2006/30446 A1, ;
Page/Page column 22-26; 28 ;
反应条件
potassium carbonate; tetrabutylammomium bromide in water T=90°C; 2 - 3 h; Product distribution / selectivity;
参考文献
WO2007/118923 A1, ;
Page/Page column 7-8 ;
反应条件
1: 96 percent / NaHCO3 / CH2Cl2 / 4 h / 20 °C 2: 61.5 percent / N,N-dimethylacetamide; aluminium trichloride / 2 h / 150 - 160 °C 3: 83 percent / NaOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 56, # 10 p. 673 - 677
反应条件
1: 61.5 percent / N,N-dimethylacetamide; aluminium trichloride / 2 h / 150 - 160 °C 2: 83 percent / NaOH / ethanol / 2.5 h / Heating View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 56, # 10 p. 673 - 677
反应条件
1: sodium hydrogencarbonate / acetonitrile / 0 °C 2: AlCl3, aluminium chloride / dichloromethane 3: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
1: AlCl3, aluminium chloride / dichloromethane 2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 60 °C View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 14 p. 7959 - 7966
反应条件
potassium carbonate in acetonitrile 2 - 3 h; Heating / reflux; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES, LTD.; TEVA PHARMACEUTICAL USA, INC.
Patent: WO2005/77904 A1, 2005 ;
Location in patent: Page/Page column 6 ;
反应条件
triethylamine in acetonitrile T=30 - 81°C; 4 - 5 h; Product distribution / selectivity;
参考文献
CADILA PHARMACEUTICALS LIMITED
Patent: WO2008/1188 A2, 2008 ;
Location in patent: Page/Page column 9-10 ;
