2-(吡啶-4-基)乙腈合成路线 （共 18 条）
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.75 h; 2: 4-bromo-pyridine in tetrahydrofuran; hexane T=-78 - 20°C; Alkylation; 2.5 h;
参考文献
Skerlj; Bogucki; Bridger
Synlett, 2000 , # 10 p. 1488 - 1490
反应条件
in dimethyl sulfoxide 3 h; Ambient temperature;
参考文献
Hung; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 741 - 744
反应条件
in dimethyl sulfoxide 2.5 h;
参考文献
Borne, Ronald F.; Aboul-Enein, Hassan Y.
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 1609 - 1611
反应条件
sodium amide; sodium t-butanolate 1) DME, 40 deg C, 2 h 2) -40 deg C, 15 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Tetrahedron Letters, , vol. 31, # 52 p. 7599 - 7602
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: 52 percent 2: 90 percent / H2O; methanol View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: 52 percent 2: 78 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Mayer, Joachim M.; Testa, Bernard
Helvetica Chimica Acta, 1982 , vol. 65, # 6 p. 1868 - 1884
反应条件
1: anh.Cs2CO3 / acetonitrile / 2 h / Heating 2: Triton B / 2-methyl-propan-2-ol / 2 h 3: conc. H2SO4 / acetic acid / 3 h / Heating View Scheme
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
反应条件
1: RhCl3*3H2O, Ph3P, anh. Na2CO3 / 20 h / Heating 2: Triton B / 2-methyl-propan-2-ol / 2 h 3: conc. H2SO4 / acetic acid / 3 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 9 p. 1550 - 1554
反应条件
1: 61 percent / RhCl3*3H2O, Ph3P, anh. NaHCO3 / 20 h / Heating 2: Triton B / 2-methyl-propan-2-ol / 3 h 3: 4.17 g / conc. H2SO4 / acetic acid / 3 h / Heating 4: 90 percent / Cs2CO3 / acetonitrile / 0.5 h / Heating View Scheme
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
