3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
N,N,N',N,-tetramethylethylenediamine; ((Me)N2N)Ni-Cl in tetrahydrofuran T=20°C; Kumada-Corriu-Tamao coupling reaction; 2 h; Inert atmosphere;
参考文献
Vechorkin, Oleg; Proust, Valerie; Hu, Xile
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9756 - 9766
反应条件
1: 4-methoxyphenyl magnesium bromide With bismuth(III) chloride 2: 5-Bromothiophene-2-carboxaldehyde With potassium phosphate; palladium diacetate; triphenylphosphine in N,N-dimethyl-formamide T=90°C; 1 h; Inert atmosphere;
参考文献
Rao, Maddali L. N.; Banerjee, Debasis; Dhanorkar, Ritesh J.
Synlett, 2011 , # 9 p. 1324 - 1330
反应条件
1: cadmium chloride; diethyl ether; benzene / Erwaermen der vom Aether befreiten Reaktionsloesung mit Bernsteinsaeure-methylester-chlorid 2: potassium hydroxide; diethylene glycol; hydrazine hydrate / 200 °C / Erwaermen des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat 3: benzene; ethanol View Scheme
参考文献
Dauben; Tanabe
Journal of the American Chemical Society, 1949 , vol. 71, p. 2877
反应条件
1: 4-methoxyphenyl magnesium bromide With (DABCO)*(SO2)2 in tetrahydrofuran T=-40°C; 1 h; Inert atmosphere; 2: (6-chloro-pyridin-3-yl)(4-methoxyphenyl)iodonium triflate in N,N-dimethyl-formamide T=120°C; 5 h; Inert atmosphereMicrowave irradiation;
参考文献
Deeming, Alex S.; Russell, Claire J.; Hennessy, Alan J.; Willis, Michael C.
Organic Letters, 2014 , vol. 16, # 1 p. 150 - 153
反应条件
1: diethyl ether 2: SOCl2; toluene / Erhitzen des Reaktionsprodukts unter vermindertem Druck 3: palladium/charcoal; ethanol / Hydrogenation 4: aqueous HBr; acetic acid View Scheme
参考文献
Rogers et al.
Journal of the American Chemical Society, 1953 , vol. 75, p. 2991,2999
反应条件
(i) THF, (ii) /BRN= 105248/; Multistep reaction;
参考文献
Ramadas,S.R.; Srinivasan,P.S.
Journal fuer Praktische Chemie (Leipzig), 1977 , vol. 319, p. 169 - 173
反应条件
diethyl ether Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Aluminiumoxyd unter vermindertem Druck auf 280grad;
参考文献
Davies,K.M.; Hickinbottom,W.J.
Journal of the Chemical Society, 1963 , p. 373 - 378
反应条件
in diethyl ether; benzene 3 h; Heating;
参考文献
Tomimatsu, Kiminori; Kataoka, Tadashi; Shimizu, Hiroshi; Hori, Mikio
Phosphorus and Sulfur and the Related Elements, 1983 , vol. 16, p. 97 - 110
反应条件
in diethyl ether; benzene 3 h; Heating;
参考文献
Tomimatsu, Kiminori; Kataoka, Tadashi; Shimizu, Hiroshi; Hori, Mikio
Phosphorus and Sulfur and the Related Elements, 1983 , vol. 16, p. 97 - 110
反应条件
1: 4-methoxyphenyl magnesium bromide With C24H52Cl2O12P4Pd2 in tetrahydrofuran; 1,4-dioxane T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: toluene-4-sulfonic acid 4-tert-butylcyclohex-1-en-1-yl ester in tetrahydrofuran; 1,4-dioxane T=80°C; Kumada-Corriu cross-coupling reaction; 24 h; Inert atmosphere;
参考文献
Ackermann, Lutz; Kapdi, Anant R.; Fenner, Sabine; Kornhaab, Christoph; Schulzke, Carola
Chemistry - A European Journal, 2011 , vol. 17, # 10 p. 2965 - 2971
