2-(2-苯基乙炔基)吡啶合成路线 （共 60 条）
反应条件
C18H19N3O2Pd; caesium carbonate in N,N-dimethyl-formamide
T=140°C; 1 h;
参考文献
Reddy, Police Vishnuvardhan; Srinivas, Pottabathula; Annapurna, Manne; Bhargava, Suresh; Wagler, Jorg; Mirzadeh, Nedaossadat; Kantam, Mannepalli Lakshmi
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 705 - 710
反应条件
copper(l) iodide; tetrabutylammomium bromide; triphenylphosphine in water
T=120°C; 0.333333 h; Microwave irradiation;
参考文献
Cordoba, Marta; Izquierdo, M. Luisa; Alvarez-Builla, Julio
Tetrahedron Letters, 2011 , vol. 52, # 15 p. 1738 - 1741
反应条件
1.1: n-butyllithium; N,N,N',N,-tetramethylethylenediamine / tetrahydrofuran; hexane / 0.05 h / -98 °C / Inert atmosphere
1.2: 2 h / -98 - -60 °C / Inert atmosphere
1.3: Inert atmosphere
2.1: Cl2Ni(1,2-bis(diphenylphosphino)ethane); 1,1-dimethylethylmagnesium chloride / tetrahydrofuran; dichloromethane / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
1: pyrrolidine; 4-laurylbenzenesulfonic acid sodium salt; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; Najera palladacycle I; water / 0.5 h / 130 °C / |Microwave irradiation; |Sealed tube; |Green chemistry
2: pyrrolidine; 4-laurylbenzenesulfonic acid sodium salt; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl; Najera palladacycle I / water / 0.5 h / 130 °C / |Microwave irradiation; |Sealed tube; |Green chemistry
View Scheme
参考文献
Buxaderas, Eduardo; Alonso, Diego A.; Najera, Carmen
European Journal of Organic Chemistry, 2013 , # 26 p. 5864 - 5870
反应条件
bis-triphenylphosphine-palladium(II) chloride in chloroform-d1
Kinetics; byproducts: (CH3)3SnBr; 50°C, freshly prepd. catalyst soln.; H-NMR;
参考文献
Wright, Michael E.
Organometallics, 1989 , vol. 8, p. 407 - 411
反应条件
1: bromine / acetic acid
2: potassium hydroxide / ethanol / |Reflux
View Scheme
参考文献
Zhuang, Junpeng; Zhang, Shuguang; Hao, Haijun; Jiang, Long
Journal of Photochemistry and Photobiology A: Chemistry, 2013 , vol. 270, p. 14 - 18
反应条件
(AuC2Ph)n; benzoyl chloride in hexane
T=70°C; 1 h; further acetylides; further solvents; variation of reaction time and temperature; Product distribution;
参考文献
Nishiwaki, Nagatoshi; Minakata, Satoshi; Komatsu, Mitsuo; Ohshiro, Yoshiki
Chemistry Letters, 1989 , p. 773 - 776
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
1.3: tetrahydrofuran; hexane / 2 h / 20 °C
2.1: 135.8 mg / lithium hexamethyldisilazide / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
View Scheme
参考文献
Orita, Akihiro; Ye, Fangguo; Babu, Govindarajulu; Ikemoto, Tomohiro; Otera, Junzo
Canadian Journal of Chemistry, 2005 , vol. 83, # 6-7 p. 716 - 727
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C
1.2: tetrahydrofuran; hexane / -78 °C
1.3: tetrahydrofuran; hexane / 20 °C
2.1: lithium hexamethyldisilazide / tetrahydrofuran; hexane / -78 - 20 °C
View Scheme
参考文献
Orita, Akihiro; Ye, Fangguo; Babu, Govindarajulu; Ikemoto, Tomohiro; Otera, Junzo
Canadian Journal of Chemistry, 2005 , vol. 83, # 6-7 p. 716 - 727
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: tetrahydrofuran; hexane / 1 h / -78 °C
1.3: tetrahydrofuran; hexane / 2 h / 20 °C
2.1: 135.8 mg / lithium hexamethyldisilazide / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
View Scheme
参考文献
Orita, Akihiro; Ye, Fangguo; Babu, Govindarajulu; Ikemoto, Tomohiro; Otera, Junzo
Canadian Journal of Chemistry, 2005 , vol. 83, # 6-7 p. 716 - 727
