1,2,3,4-四氢-9-吖啶酮合成路线 （共 21 条）
反应条件
1: trichlorophosphate / toluene-4-sulfonic acid / 120 °C 2: sulfuric acid / 120 °C View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: trichlorophosphate / toluene-4-sulfonic acid / 120 °C 2: sulfuric acid / 120 °C View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: 90 percent / 58 h / Heating 2: 76 percent / Ac2O, pyridine / 2 h / 140 °C 3: 90 percent / 10percent HCl / 1 h / Heating View Scheme
参考文献
Yamato, Masatoshi; Takeuchi, Yasuo; Ikeda, Yuji
Heterocycles, 1987 , vol. 26, # 1 p. 191 - 197
反应条件
1: 76 percent / Ac2O, pyridine / 2 h / 140 °C 2: 90 percent / 10percent HCl / 1 h / Heating View Scheme
参考文献
Yamato, Masatoshi; Takeuchi, Yasuo; Ikeda, Yuji
Heterocycles, 1987 , vol. 26, # 1 p. 191 - 197
反应条件
N,N-dimethyl-cyclohexylamine; phosphorus pentoxide 1.) RT, 2.) 210 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Finlander, Peter; Fischer, Hans Peter; Pedersen, Erik Bjerregaard
Heterocycles, 1985 , vol. 23, # 6 p. 1437 - 1444
反应条件
1: 100 percent / POCl3 / 3 h / Heating 2: pentan-1-ol / Heating View Scheme
参考文献
Dorronsoro, Isabel; Alonso, Diana; Castro, Ana; Del Monte, Maria; Garcia-Palomero, Esther; Martinez, Ana
Archiv der Pharmazie, 2005 , vol. 338, # 1 p. 18 - 23
反应条件
trichlorophosphate 3 h; Heating;
参考文献
Dorronsoro, Isabel; Alonso, Diana; Castro, Ana; Del Monte, Maria; Garcia-Palomero, Esther; Martinez, Ana
Archiv der Pharmazie, 2005 , vol. 338, # 1 p. 18 - 23
反应条件
1: tetraphosphorus decasulfide; N,N'-dimethyl-N,N'-propyleneurea / 95 °C
2: phenol / 80 °C
3: trichlorophosphate / 120 °C
View Scheme
参考文献
THE BRIGHAM AND WOMEN'S HOSPITAL, INC.; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; UNIVERSITY PAUL CEZANNE MARSEILLE III/AIX; HIGGINS, Jonathan; CUNY, Gregory D.; GLICKSMAN, Marcie; PATNAIK, Debasis; ROBIN, Maxime; STEIN, Ross L.; XIAN, Jun
Patent: WO2011/127406 A2, 2011 ;
WO 2011/127406 A2
反应条件
1: POCl3 / 3 h / Heating
2: phenol, NaI / 1.5 h / 130 °C
View Scheme
参考文献
Yamato; Takeuchi; Hashigaki; Ikeda; Ming-Rong; Matsushima; Tsuruo; Tashiro; Tsukagoshi; Yamashita; Nakano
Journal of Medicinal Chemistry, 1989 , vol. 32, # 6 p. 1295 - 1300
反应条件
1: 85 percent / POCl3 / 2 h / 120 °C
2: 1 h / 110 °C
3: 20 h / 135 °C
View Scheme
参考文献
Michalson, Eric T.; D'Andrea, Stan; Freeman, Jeremiah P.; Szmuszkovicz, Jacob
Heterocycles, 1990 , vol. 30, # 1 p. 415 - 425
